| Name | cytochrome P450 2E1 |
|---|---|
| Synonyms | CPE 1; Flavoprotein linked monooxygenase; Xenobiotic monooxygenase; Microsomal monooxygenase; CPE1; CYP2E; CYP2E1; CYP2E1 protein… |
| Name | chloroform |
|---|---|
| CAS | trichloromethane |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18350910 | James CA, Xin G, Doty SL, Strand SE: Degradation of low molecular weight volatile organic compounds by plants genetically modified with mammalian cytochrome P450 2E1. Environ Sci Technol. 2008 Jan 1;42(1):289-93. Cytochrome P450 2E1 (CYP2E1) is a key enzyme in the mammalian metabolism of several low molecular weight volatile organic compounds (VOCs), such as trichloroethylene (TCE), vinyl (VC), carbon tetrachloride (CT), chloroform, and bromodichloromethane (BDCM), which are all common environmental pollutants that pose risks to human health. |
33(0,1,1,3) | Details |
| 17660703 | Qin LQ, Wang Y, Xu JY, Kaneko T, Sato A, Wang PY: One-day dietary restriction changes hepatic metabolism and potentiates the hepatotoxicity of carbon tetrachloride and chloroform in rats. Tohoku J Exp Med. 2007 Aug;212(4):379-87. In the present study, we fed male Wistar rats at five levels of food intake for one day, including conventional feeding (60 kcal), three of DR (45, 30, and 15 kcal), and fasting (0 kcal), and observed the metabolic changes of hepatic cytochrome P450 2E1 (CYP2E1) and the hepatotoxicity of chloroform (CHCl (3)) and carbon tetrachloride (CCl (4)). |
8(0,0,1,3) | Details |
| 17533807 | Diaz Gomez MI, Fanelli SL, Delgado de Layno AM, Castro JA, Castro GD: Liver nuclear and microsomal CYP2E1-mediated metabolism of xenobiotics in rats chronically drinking an -containing liquid diet. Toxicol Ind Health. 2006 Oct;22(9):367-74. In previous studies from our laboratory, the presence in highly purified liver nuclei of metabolic pathways for processing (EtOH), N-nitrosodimethylamine (NDMA), carbon tetrachloride and chloroform was reported. |
4(0,0,0,4) | Details |
| 20030633 | Boobis AR: Mode of Action Considerations in the Quantitative Assessment of Tumour Responses in the Liver. Basic Clin Pharmacol Toxicol. 2009 Dec 17. This compound is converted to a cytotoxic metabolite, phosgene, by CYP2E1 in liver and/or kidney. The approaches discussed are illustrated using chloroform as a case study. |
2(0,0,0,2) | Details |
| 19391120 | Gotohda T, Nishimura A, Morita K: Immunohistochemical studies on early stage of hepatic damage induced by subacute inhalation of toluene vapor in rats. J Appl Toxicol. 2009 Aug;29(6):505-9. Although hepatic cells are generally considered to be vulnerable and susceptible to various organic solvents, particularly chloroform and other halogenated hydrocarbons, the hepatotoxic effects of aromatic hydrocarbons including toluene have not yet been sufficiently characterized. The immunoreactivities of heat shock proteins (HSP-70 and HSP-90) and cytochrome P4502E1 (CYP2E1) in the liver were analyzed to assess the hepatotoxic damage induced by toluene inhalation, and the expression of these histological markers was shown to be substantially enhanced by the subacute exposure to toluene vapor. |
1(0,0,0,1) | Details |
| 17940038 | Doty SL, James CA, Moore AL, Vajzovic A, Singleton GL, Ma C, Khan Z, Xin G, Kang JW, Park JY, Meilan R, Strauss SH, Wilkerson J, Farin F, Strand SE: Enhanced phytoremediation of volatile environmental pollutants with transgenic trees. Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):16816-21. Epub 2007 Oct 16. Small, volatile hydrocarbons, including trichloroethylene, vinyl carbon tetrachloride, and chloroform, are common environmental pollutants that pose serious health effects. We have developed transgenic poplar (Populus tremula x Populus alba) plants with greatly increased rates of metabolism and removal of these pollutants through the overexpression of cytochrome P450 2E1, a key enzyme in the metabolism of a variety of halogenated compounds. |
1(0,0,0,1) | Details |