| Name | caspase 3 |
|---|---|
| Synonyms | Apopain; CASP 3; CASP3; CPP 32; CPP32; CPP32B; Caspase 3; Caspase 3 precursor… |
| Name | chloroform |
|---|---|
| CAS | trichloromethane |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 20150224 | Ooi KL, Tengku Muhammad TS, Lim CH, Sulaiman SF: Apoptotic effects of Physalis minima L. chloroform extract in human breast carcinoma T-47D cells mediated by c-myc-, p53-, and caspase-3-dependent pathways. Integr Cancer Ther. 2010 Mar;9(1):73-83. Epub 2010 Feb 11. |
94(1,1,3,4) | Details |
| 19035296 | Nomura M, Takahashi T, Uesugi A, Tanaka R, Kobayashi S: Inotodiol, a lanostane triterpenoid, from Inonotus obliquus inhibits cell proliferation through caspase-3-dependent apoptosis. Anticancer Res. 2008 Sep-Oct;28(5A):2691-6. BACKGROUND: To investigate the antitumor effect of Inonotus obliquus Pilat, the antiproliferative effect of lanostane triterpenoids from a chloroform extract of I. obliquus sclerotia against mouse leukemia P388 cells was assessed. |
5(0,0,0,5) | Details |
| 20045455 | Ooi KL, Muhammad TS, Sulaiman SF: Growth arrest and induction of apoptotic and non-apoptotic programmed cell death by, Physalis minima L. chloroform extract in human ovarian carcinoma Caov-3 cells. J Ethnopharmacol. 2010 Mar 2;128(1):92-9. Epub 2010 Jan 4. The mechanism of cell death was determined using four independent methods, namely DeadEnd assay to label the DNA fragmentation nuclei cells, RT-PCR analysis to determine the mRNA expression level of three apoptotic genes (c-myc, p53 and caspase-3 genes), Transmission Electron Microscope (TEM) analysis to describe the ultra structural characteristics and annexin V and propidium iodide staining to confirm the types and stages of cell deaths. |
3(0,0,0,3) | Details |
| 19541726 | Leong OK, Muhammad TS, Sulaiman SF: Cytotoxic Activities of Physalis minima L. Evid Based Complement Alternat Med. 2009 Jun 18. Chloroform Extract on Human Lung Adenocarcinoma NCI-H23 Cell Lines by Induction of Apoptosis.. Furthermore, acute exposure to the extract produced a significant regulation of c-myc, caspase-3 and p53 mRNA expression in this cell line. |
1(0,0,0,1) | Details |
| 18577687 | Chen YL, Jian MH, Lin CC, Kang JC, Chen SP, Lin PC, Hung PJ, Chen JR, Chang WL, Lin SZ, Harn HJ: The induction of orphan nuclear receptor Nur77 expression by n-butylenephthalide as pharmaceuticals on hepatocellular carcinoma cell therapy. Mol Pharmacol. 2008 Oct;74(4):1046-58. Epub 2008 Jun 24. N-butylidenephthalide (BP), isolated from the chloroform extract of Angelica sinensis, has been examined for its antitumor effects on glioblastoma multiforme brain tumors; however, little is known about its antitumor effects on hepatocellular carcinoma cells. Furthermore, N-butylidenephthalide-induced apoptosis seems to be related to Nur77 translocation from nucleus to cytosol, which leads to cytochrome c release and caspase-3-dependent apoptosis. |
1(0,0,0,1) | Details |
| 17639562 | Wu YD, Lou YJ: A steroid fraction of chloroform extract from bee pollen of Brassica campestris induces apoptosis in human prostate cancer PC-3 cells. Phytother Res. 2007 Nov;21(11):1087-91. Caspase-3 activity was obviously enhanced after the cells were treated with the fraction. |
1(0,0,0,1) | Details |
| 18419761 | Lin PC, Chen YL, Chiu SC, Yu YL, Chen SP, Chien MH, Chen KY, Chang WL, Lin SZ, Chiou TW, Harn HJ: Orphan nuclear receptor, Nurr-77 was a possible target gene of butylidenephthalide chemotherapy on glioblastoma multiform brain tumor. J Neurochem. 2008 Aug;106(3):1017-26. Epub 2008 Apr 17. The natural compound n-butylidenephthalide (BP), which is isolated from the chloroform extract of Angelica sinensis, has been investigated for its antitumoral effects on glioblastoma multiform (GBM) brain tumors both in vitro and in vivo. After BP treatment in GBM 8401 cells, Nur77 translocated from the nucleus to the cytoplasm, the cytochrome c was released from the mitochondria, and caspase 3 became activated. |
1(0,0,0,1) | Details |
| 17704652 | Rho YH, Lee BW, Park KH, Bae YS: Cudraflavanone A purified from Cudrania tricuspidata induces apoptotic cell death of human leukemia U937 cells, at least in part, through the inhibition of DNA topoisomerase I and protein kinase C activity. Anticancer Drugs. 2007 Oct;18(9):1023-8. A chloroform extract of the root bark of Cudrania tricuspidata showed an inhibitory effect on mammalian DNA topoisomerase I. Cudraflavanone A-induced cell death was characterized by the cleavage of poly (ADP- polymerase and pro-caspase-3. |
1(0,0,0,1) | Details |
| 17935706 | Verma M, Singh SK, Bhushan S, Sharma VK, Datt P, Kapahi BK, Saxena AK: In vitro cytotoxic potential of Polyalthia longifolia on human cancer cell lines and induction of apoptosis through mitochondrial-dependent pathway in HL-60 cells. Chem Biol Interact. 2008 Jan 10;171(1):45-56. Epub 2007 Sep 1. We are reporting first time the anticancer potential of P. longifolia leaves extract (A001) and its chloroform fraction (F002). F002 induce apoptotic bodies formation, DNA ladder, enhanced annexin-V-FITC binding of the cells, increased sub-G (0) DNA fraction, loss of mitochondrial membrane potential (DeltaPsi (mt)), release of cytochrome c, activation of caspase-9, caspase-3, and cleavage of poly ADP polymerase (PARP) in HL-60 cells. |
1(0,0,0,1) | Details |
| 17613819 | Rho YH, Yoon SH, Kim EK, Kang JY, Lee BW, Park KH, Bae YS: 2',5,7-Trihydroxy-4',5'-(2,2-dimethylchromeno)-8-(3--3-methylbutyl) flavanone purified from Cudrania tricuspidata induces apoptotic cell death of human leukemia U937 cells. Nat Prod Res. 2007 Jun;21(7):616-24. A chloroform extract of the root barks of Cudrania tricuspidata showed an inhibitory effect on mammalian DNA topoisomerase I. PKH-3-induced cell death was characterized with the cleavage of poly (ADP- polymerase (PARP) and pro-caspase 3. |
1(0,0,0,1) | Details |
| 19662576 | Bae JS, Park JW, Park SH, Park JB, Rho YH, Ryu YB, Lee KS, Park KH, Bae YS: Apoptotic cell death of human leukaemia U937 cells by -9 purified from Pleurotus eryngii. Nat Prod Res. 2009;23(12):1112-9. A chloroform extract of the edible mushroom Pleurotus eryngii showed an inhibitory effect on mammalian DNA topoisomerase I. -9-induced cell death was characterised with the cleavage of poly (ADP- polymerase and pro-caspase 3. |
1(0,0,0,1) | Details |