Protein Information

Name Acetylcholinesterase
Synonyms ACHE; ACHE protein; AChE; ARACHE; AcChoEase; Acetylcholine acetylhydrolase; Acetylcholinesterase; Acetylcholinesterase isoform E4 E6 variant…

Compound Information

Name chloroform
CAS trichloromethane

Reference List

PubMed Abstract RScore(About this table)
18237027 Ahmad B, Mukarram Shah SM, Khan H, Hassan Shah SM: Enzyme inhibition activities of Teucrium royleanum. J Enzyme Inhib Med Chem. 2007 Dec;22(6):730-2.

The crude methanolic extract and chloroform, ethyl acetate and n-butanol fractions of Teucrium royleanum were examined as inhibitors of actylcholinesterase, butyrylcholinesterase, lipoxygenase and urease.
A significant enzyme inhibition activity (52-83%) was shown by the crude methanolic extract and its fractions against acetylcholinesterase, while low to outstanding enzyme inhibitory activity was shown (19-93%) against butyrylcholinesterase.
1(0,0,0,1) Details
18237025 Khan H, Khan MA, Hussan I: Enzyme inhibition activities of the extracts from rhizomes of Gloriosa superba Linn (Colchicaceae). J Enzyme Inhib Med Chem. 2007 Dec;22(6):722-5.


The crude extract and its subsequent fractions including chloroform, ethyl acetate, n-butanol and aqueous were screened against lipoxygenase, actylcholinesterase, butyrylcholinesterase and urease.
0(0,0,0,0) Details
17518351 Ahmad B, Shah SM, Bashir S, Shah J: Enzyme inhibition activities of Andrachne cardifolia Muell. J Enzyme Inhib Med Chem. 2007 Apr;22(2):235-8.

The crude methanolic extract and various fractions of Andrachne cardifolia Muell, including chloroform, ethyl acetate and n-butanol fractions were subjected to in vitro enzyme inhibition activity against acetylcholinesterase, butyrylcholinesterase, lipoxygenase and urease enzymes.
81(1,1,1,1) Details
19285534 Orhan I, Senol FS, Gulpinar AR, Kartal M, Sekeroglu N, Deveci M, Kan Y, Sener B: Acetylcholinesterase inhibitory and antioxidant properties of Cyclotrichium niveum, Thymus praecox subsp. caucasicus var. caucasicus, Echinacea purpurea and E. pallida. Food Chem Toxicol. 2009 Jun;47(6):1304-10. Epub 2009 Mar 12.

The water extracts of CN and TP and the chloroform extract of the aerial parts of EPU displayed the highest ferrous ion-chelating effect.
4(0,0,0,4) Details
20144879 Visweswari G, Prasad KS, Chetan PS, Lokanatha V, Rajendra W: Evaluation of the anticonvulsant effect of Centella asiatica (gotu kola) in pentylenetetrazol-induced seizures with respect to cholinergic neurotransmission. Epilepsy Behav. 2010 Mar;17(3):332-5. Epub 2010 Feb 9.

Rats were randomly divided into eight groups of six rats each: nonepileptic rats treated with saline; PTZ (60 mg/kg, IP)-induced seizure rats treated with saline; PTZ-induced seizure rats pretreated with n-hexane, chloroform, ethyl acetate, n-butanol, and water extracts of C. asiatica; and PTZ-induced seizure rats pretreated with diazepam (2mg/kg body wt).
Increased acetylcholine content and decreased acetylcholinesterase activity were recorded in different brain regions during PTZ-induced seizures.
2(0,0,0,2) Details
19384728 Orhan I, Ozcelik B, Aslan S, Kartal M, Karaoglu T, Sener B, Terzioglu S, Iqbal Choudhary M: In vitro biological activity screening of Lycopodium complanatum L. ssp. chamaecyparissus (A. Nat Prod Res. 2009;23(6):514-26.

This article reports the results of selected biological activities, including anticholinesterase, antioxidant, antibacterial, antifungal and antiviral properties, of the petroleum ether, chloroform and methanol extracts as well as the alkaloid fraction of Lycopodium complanatum L. ssp. chamaecyparissus (A.
Anticholinesterase effect of the extracts was tested against both acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) at concentrations of 0.2 and 1 mg mL (-1) using microplate-reader assay based on Ellman method.
2(0,0,0,2) Details