Protein Information

Name Peroxisome proliferator activated receptors
Synonyms NR1C1; PPAR; PPAR alpha; PPARA; PPARalpha; Peroxisome proliferator activated receptor; Peroxisome proliferator activated receptor alpha; hPPAR…

Compound Information

Name chloroform
CAS trichloromethane

Reference List

PubMed Abstract RScore(About this table)
19606518 Kubota H, Morii R, Kojima-Yuasa A, Huang X, Yano Y, Matsui-Yuasa I: Effect of Zizyphus jujuba extract on the inhibition of adipogenesis in 3T3-L1 preadipocytes. Am J Chin Med. 2009;37(3):597-608.

Further fractionation of the initial Z .jujuba extract with organic solvent revealed that the chloroform fraction (CHCl (3)-F) elicited the most inhibitory effect, which involved significant attenuation of the expression of key adipogenic transcription factors, including peroxisome proliferator-activated receptor (PPAR) gamma and CCAAT enhancer binding proteins (C/EBPs) at the protein level.
81(1,1,1,1) Details
19242902 Dat NT, Lee K, Hong YS, Kim YH, Minh CV, Lee JJ: A peroxisome proliferator-activated receptor-gamma agonist and other constituents from Chromolaena odorata. Planta Med. 2009 Jun;75(8):803-7. Epub 2009 Feb 25.

Peroxisome proliferator-activated receptors (PPARs) are key regulators of lipid and glucose metabolism and have become important therapeutic targets for various diseases.
The phytochemical investigation of the chloroform-soluble extract of Chromolaena odorata led to the isolation of a PPAR-gamma agonist, (9 S,13 R)-12-oxo-phytodienoic acid (1), together with 12 other compounds.
1(0,0,0,1) Details