Protein Information

Name interleukin 6
Synonyms 26 kd protein; B cell differentiation factor; B cell stimulatory factor 2; BSF 2; BSF2; CDF; CTL differentiation factor; HGF…

Compound Information

Name chloroform
CAS trichloromethane

Reference List

PubMed Abstract RScore(About this table)
19917107 Fostok SF, Ezzeddine RA, Homaidan FR, Al-Saghir JA, Salloum RG, Saliba NA, Talhouk RS: Interleukin-6 and Cyclooxygenase-2 downregulation by fatty-acid fractions of Ranunculus constantinopolitanus. BMC Complement Altern Med. 2009 Nov 16;9:44.

RESULTS: The chloroform fraction (I.2) derived from crude MeOH extract of the plant, in addition to Y2+3, a FA mix isolated from this fraction and containing palmitic acid, C18:2 and C18:1 isomers and stearic acid (1:5:8:1 ratio), reduced ET-induced IL-6 levels in SCp2 cells without affecting cell viability or morphology.
34(0,1,1,4) Details
17472475 Lee Y, Park H, Ryu HS, Chun M, Kang S, Kim HS: Effects of elm bark (Ulmus davidiana var. japonica) extracts on the modulation of immunocompetence in mice. J Med Food. 2007 Mar;10(1):118-25.

The immunomodulative effects of elm bark extract were studied in vitro by the proliferation of splenocytes and the production capacity of three kinds of cytokines [interleukin (IL)-1beta, IL-6, and tumor necrosis factor (TNF)-alpha] by mouse peritoneal macrophages cultured with various fractions (methanol, hexane, chloroform, ethyl acetate, butanol, and water) of elm bark extract.
33(0,1,1,3) Details
18163209 Timasheva YR, Nasibullin TR, Zakirova AN, Mustafina OE: Association of interleukin-6, interleukin-12, and interleukin-10 gene polymorphisms with essential hypertension in Tatars from Russia. Biochem Genet. 2008 Feb;46(1-2):64-74. Epub 2007 Dec 28.

DNA was isolated from whole venous blood using phenol-chloroform extraction by the standard method.
4(0,0,0,4) Details
18321049 Wu LC, Fan NC, Lin MH, Chu IR, Huang SJ, Hu CY, Han SY: Anti-inflammatory effect of spilanthol from Spilanthes acmella on murine macrophage by down-regulating LPS-induced inflammatory mediators. J Agric Food Chem. 2008 Apr 9;56(7):2341-9. Epub 2008 Mar 6.

Additionally, the LPS-stimulated IL-1beta, IL-6, and TNF-alpha productions are dose-dependently reduced by spilanthol.
Extracts of S. acmella are obtained by extraction with 85% ethanol, followed by liquid partition against hexane, chloroform, ethyl acetate, and butanol.
1(0,0,0,1) Details