| Name | dopamine transporter |
|---|---|
| Synonyms | DA transporter; DAT1; DAT; DAT 1; Dopamine transporter; SLC6A3; Sodium dependent dopamine transporter; Dopamine transporters… |
| Name | chloroform |
|---|---|
| CAS | trichloromethane |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19527825 | Zhao G, Zheng XW, Gai Y, Chu WJ, Qin GW, Guo LH: Safflower extracts functionally regulate monoamine transporters. J Ethnopharmacol. 2009 Jul 6;124(1):116-24. Epub 2009 Apr 10. Our current results showed that all solvent-extracted HH fractions, in different degrees, markedly increased both uptake by Chinese hamster ovary (CHO) cells stably expressing dopamine transporter (DAT) and uptake by CHO cells expressing norepinephrine transporter (NET), and also showed that chloroform (HC), ethyl (HE), and extract strikingly depressed uptake by CHO cells expressing serotonin transporter (SERT); wherein, the potencies of extract, HC, HE, and aqueous extract to up-regulate / uptake and potency of HE to inhibit uptake were relatively stronger. |
31(0,1,1,1) | Details |
| 19491370 | Zhao G, Bi C, Qin GW, Guo LH: Caulis Sinomenii extracts activate DA/NE transporter and inhibit 5HT transporter. Exp Biol Med. 2009 Aug;234(8):976-85. Epub 2009 Jun 2. We assessed whether QFT would be biologically active in functionally regulating monoamine transporters using CHO cells expressing dopamine transporter (DAT), norepinephrine transporter (NET), or serotonin transporter (SERT) (i.e. Here, we showed that its primary extracts, such as QA, QC, QE, QD, and QB (QFT chloroform, ethyl alkaloid-free chloroform, and alkaloid-containing chloroform extract, respectively), and secondary extracts, such as QE-2, - 3, - 5, - 7, QD-1, - 2, - 3, - 4, - 5, and QB-1, - 2, - 3, - 4, - 5 (fractioned from QE, QD, and QB, respectively), in differing degrees, either increased DA/ NE uptake by corresponding D8/N1 cells or decreased 5HT uptake by S6 cells; wherein, QE-2, QD-3, and QE-7 were potent DA/NE uptake activators while both QE-7 and QB-5 were potent 5HT uptake inhibitors. |
1(0,0,0,1) | Details |
| 20084455 | Zhao G, Wang J, Qin GW, Guo LH: Cynomorium songaricum extracts functionally modulate transporters of and monoamine. Neurochem Res. 2010 Apr;35(4):666-76. Here, we assessed these potential actions using Chinese hamster ovary cells expressing (GABA) transporter (GAT-1), dopamine transporter (DAT), norepinephrine transporter (NET), or serotonin transporter (SERT) (i.e. It was shown that SY extracts, such as SYw, SYa, SYp, SYc, SYe, and SYb (SY water, petroleum ether, chloroform, ethyl and extract, respectively) increased / (DA/NE) uptake by corresponding D8/N1 cells and decreased /serotoin /5HT) uptake by corresponding G1/S6 cells; wherein, the potency or efficacy of SYc for up-regulating DA/NE uptake and that of SYb for inhibiting /5HT uptake were relatively stronger. |
1(0,0,0,1) | Details |