| Name | alanine aminotransferase |
|---|---|
| Synonyms | AAT1; AAT1; GPT; ALT 1; ALT1; Alanine aminotransferase; Alanine aminotransferase 1; GPT 1… |
| Name | chloroform |
|---|---|
| CAS | trichloromethane |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17966065 | Burke AS, Redeker K, Kurten RC, James LP, Hinson JA: Mechanisms of chloroform-induced hepatotoxicity: oxidative stress and mitochondrial permeability transition in freshly isolated mouse hepatocytes. J Toxicol Environ Health A. 2007 Nov;70(22):1936-45. Incubation of chloroform (12 mM) with hepatocytes resulted in cell death (alanine aminotransferase release and propidium iodide fluorescence). |
6(0,0,1,1) | Details |
| 20067861 | Roy CK, Das AK: Comparative evaluation of different extracts of leaves of Psidium guajava Linn. for hepatoprotective activity. Pak J Pharm Sci. 2010 Jan;23(1):15-20. The study was designed to evaluate the hepatoprotective activity of different extracts (petroleum ether, chloroform, ethyl and aqueous) of P. guajava in acute experimental liver injury induced by carbon tetrachloride and In the acute liver damage induced by different hepatotoxins, P. guajava methanolic leaf extract (200 mg/kg, p.o.) significantly reduced the elevated serum levels of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase and in carbon tetrachloride and induced hepatotoxicity. |
2(0,0,0,2) | Details |
| 19117555 | Liu J, Drane W, Liu X, Wu T: Examination of the relationships between environmental exposures to volatile organic compounds and biochemical liver tests: application of canonical correlation analysis. Environ Res. 2009 Feb;109(2):193-9. Epub 2008 Dec 30. Serum albumin, total (TB), alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), alkaline phosphatase (ALP), and gamma-glutamyl transferase (GGT) served as the outcome variables. Personal exposures to chloroform, ethylbenzene, tetrachloroethene, toluene, trichloroethene, o-xylene, m-,p-xylene, 1,4-dichlorobenzene, and methyl tert-butyl ether (MTBE) were assessed through the use of passive exposure monitors worn by study participants. |
1(0,0,0,1) | Details |
| 20046731 | Dandagi PM, Patil MB, Mastiholimath VS, Gadad AP, Dhumansure RH: Development and evaluation of hepatoprotective polyherbal formulation containing some indigenous medicinal plants. Indian J Pharm Sci. 2008 Mar-Apr;70(2):265-8. Petroleum ether (60-80 degrees ), chloroform, and aqueous extracts of Ferula asafetida, Momordica charantia Linn and Nardostachys jatamansi were evaluated for hepatoprotective activity against carbon tetrachloride-induced liver toxicity in Wistar rats. Formulation F3 has shown significant hepatoprotective effect by reducing the elevated serum enzyme levels such as transaminase, glutamate pyruvate transaminase and alkaline phosphatase. |
1(0,0,0,1) | Details |
| 20196600 | Oh TW, Kim YA, Jang WJ, Byeon JI, Ryu CH, Kim JO, Ha YL: Semipurified Fractions from the Submerged-Culture Broth of Agaricus blazei Murill Reduce Blood Levels in Streptozotocin-Induced Diabetic Rats. J Agric Food Chem. 2010 Mar 2. The hot-water extract, treated with to remove beta-glucans and glycoproteins, was freeze-dried, and fractionated into hexane, chloroform, ethyl (EA), and butanol fractions. The EAF reduced the levels of triglyceride and in plasma, the activity of - transaminase and glutamate-pyruvate transaminase in blood, and the content of thiobarbituric acid reactive substance in the liver and kidney. |
1(0,0,0,1) | Details |
| 18831335 | Hamden K, Masmoudi H, Ellouz F, ElFeki A, Carreau S: Protective effects of Peganum harmala extracts on thiourea-induced diseases in adult male rat. J Environ Biol. 2008 Jan;29(1):73-7. The aim of our study was to characterize the putative protective effects of and chloroform extracts of Peganum harmala on thiourea-induced diseases in adult male rat. In addition the putative hepatoprotective effect was checked by the determination of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activities and the level in the blood. |
1(0,0,0,1) | Details |
| 20137904 | Oboh G, Akomolafe TL, Adefegha SA, Adetuyi AO: Inhibition of cyclophosphamide-induced oxidative stress in rat brain by polar and non-polar extracts of Annatto (Bixa orellana) seeds. Exp Toxicol Pathol. 2010 Feb 4. This study sought to assess the ability of dietary inclusion of polar (water) and non-polar (chloroform) extracts of Annatto (B. orellana) seeds on cyclophosphamide-induced oxidative stress in rat brain. Likewise, the extracts also caused dose-dependent inhibition of the elevated serum transaminase (SGOT), glutamate pyruvate transaminase (SGPT), alkaline phosphatase and total |
1(0,0,0,1) | Details |
| 17660703 | Qin LQ, Wang Y, Xu JY, Kaneko T, Sato A, Wang PY: One-day dietary restriction changes hepatic metabolism and potentiates the hepatotoxicity of carbon tetrachloride and chloroform in rats. Tohoku J Exp Med. 2007 Aug;212(4):379-87. After the challenge by CHCl (3) and CCl (4), the activities of aspartate aminotransferase and alanine aminotransferase, marker enzymes for liver damage, were elevated remarkably at all food groups. |
1(0,0,0,1) | Details |