| Name | Glut 4 |
|---|---|
| Synonyms | GLUT 4; GLUT4; Glucose transporter 4; SLC2A4; Solute carrier family 2 member 4; Glucose transporter 4s; Solute carrier family 2 member 4s |
| Name | chloroform |
|---|---|
| CAS | trichloromethane |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19744549 | Kumar R, Balaji S, Uma TS, Sehgal PK: Fruit extracts of Momordica charantia potentiate uptake and up-regulate Glut-4, PPAR gamma and PI3K. J Ethnopharmacol. 2009 Dec 10;126(3):533-7. Epub 2009 Sep 8. Effects of aqueous and chloroform extracts of Momordica charantia fruit on uptake and up-regulation of transporter (Glut-4), peroxisome proliferator activator receptor gamma (PPAR gamma) and phosphatidylinositol-3 kinase (PI3K), were investigated to show its efficacy as a hypoglycaemic agent. |
165(2,2,2,5) | Details |
| 19003111 | Teruya K, Yamashita M, Tominaga R, Nagira T, Shim SY, Katakura Y, Tokumaru S, Tokumaru K, Barnes D, Shirahata S: Fermented milk, Kefram-Kefir enhances uptake into insulin-responsive muscle cells. Cytotechnology. 2002 Nov;40(1-3):107-16. -soluble or chloroform/-extracted fractions from Kefram-Kefir were examined to evaluate the uptake ability of L6 myotubes.As a result, the water-soluble fraction augmented the uptake of in L6 myotubes both in the presence and absence of insulin stimulation. Considering together with the reports that PI 3-kinase is locatedin the insulin signaling pathway and the participation in the translocation of glucose transporter 4 to the cell membrane, it is suggested that the water-soluble fraction of Kefram-Kefir activates PI 3-kinase or other upstream molecules in the insulin signaling pathway, which resulted in the augmentation of uptake and its specific inhibition by wortmannin. |
1(0,0,0,1) | Details |