| Name | c Myc |
|---|---|
| Synonyms | MYC; Myc proto oncogene protein; Oncogene MYC; Transcription factor p64; c Myc; v myc avian myelocytomatosis viral oncogene homolog; v myc myelocytomatosis viral oncogene homolog (avian); Myc proto oncogene proteins… |
| Name | chloroform |
|---|---|
| CAS | trichloromethane |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17385831 | Minic V, Andjelic G, Stanic V, Magic Z: p53 and c-myc alterations in patients with non-small cell lung carcinoma in Serbia. J BUON. 2004 Jan-Mar;9(1):67-72. MATERIALS AND METHODS: DNA was isolated from 41 frozen tumor samples by standard -chloroform extraction. |
4(0,0,0,4) | Details |
| 20045455 | Ooi KL, Muhammad TS, Sulaiman SF: Growth arrest and induction of apoptotic and non-apoptotic programmed cell death by, Physalis minima L. chloroform extract in human ovarian carcinoma Caov-3 cells. J Ethnopharmacol. 2010 Mar 2;128(1):92-9. Epub 2010 Jan 4. The mechanism of cell death was determined using four independent methods, namely DeadEnd assay to label the DNA fragmentation nuclei cells, RT-PCR analysis to determine the mRNA expression level of three apoptotic genes (c-myc, p53 and caspase-3 genes), Transmission Electron Microscope (TEM) analysis to describe the ultra structural characteristics and annexin V and propidium iodide staining to confirm the types and stages of cell deaths. |
3(0,0,0,3) | Details |
| 19541726 | Leong OK, Muhammad TS, Sulaiman SF: Cytotoxic Activities of Physalis minima L. Evid Based Complement Alternat Med. 2009 Jun 18. Chloroform Extract on Human Lung Adenocarcinoma NCI-H23 Cell Lines by Induction of Apoptosis.. Furthermore, acute exposure to the extract produced a significant regulation of c-myc, caspase-3 and p53 mRNA expression in this cell line. |
1(0,0,0,1) | Details |
| 19399188 | Lavhale MS, Kumar S, Mishra SH, Sitasawad SL: A novel triterpenoid isolated from the root bark of Ailanthus excelsa Roxb (Tree of Heaven), AECHL-1 as a potential anti-cancer agent. PLoS One. 2009;4(4):e5365. Epub 2009 Apr 28. BACKGROUND: We report here the isolation and characterization of a new compound Ailanthus excelsa chloroform extract-1 (AECHL-1) (C (29) H (36) O (10); molecular weight 543.8) from the root bark of Ailanthus excelsa Roxb. In B16F10 tumors, AECHL-1 at 50 microg/mouse/day dose for 15 days resulted in increased expression of tumor suppressor proteins P53/p21, reduction in the expression of the oncogene c-Myc, and downregulation of cyclin D1 and cdk4. |
1(0,0,0,1) | Details |
| 18449496 | Kim JS, Lee SI, Park HW, Yang JH, Shin TY, Kim YC, Baek NI, Kim SH, Choi SU, Kwon BM, Leem KH, Jung MY, Kim DK: Cytotoxic components from the dried rhizomes of Zingiber officinale Roscoe. Arch Pharm Res. 2008 Apr;31(4):415-8. Epub 2008 May 1. Five compounds were isolated from the chloroform-soluble fraction of the methanolic extract of the dried rhizomes of Zingiber officinale (Zingiberaceae) through repeated column chromatography. Among the five isolated compounds, 6-shogaol exhibited the most potent cytotoxicity against human A549, SK-OV-3, SK-MEL-2, and HCT15 tumor cells. 6-shogaol inhibited proliferation of the transgenic mouse ovarian cancer cell lines, C1 (genotype: p53 (-/-), c-myc, K-ras) and C2 (genotype: p53 (-/-), c-myc, Akt), with ED (50) values of 0.58 microM (C1) and 10.7 microM (C2). |
1(0,0,0,1) | Details |
| 20150224 | Ooi KL, Tengku Muhammad TS, Lim CH, Sulaiman SF: Apoptotic effects of Physalis minima L. chloroform extract in human breast carcinoma T-47D cells mediated by c-myc-, p53-, and caspase-3-dependent pathways. Integr Cancer Ther. 2010 Mar;9(1):73-83. Epub 2010 Feb 11. |
94(1,1,3,4) | Details |
| 19370966 | : [Alterations of c-Myc and c-erbB-2 genes in ovarian tumours] . Srp Arh Celok Lek. 2009 Jan-Feb;137(1-2):47-51. METHODS: DNA was isolated from 15 samples of malignant and 5 benign ovarian tumours, using proteinase K digestion, followed by -chloroform isoamyl extraction and precipitation. |
7(0,0,0,7) | Details |