Protein Information

Name Tyrosinase
Synonyms LB24 AB; Monophenol monooxygenase; OCA1A; OCAIA; SK29 AB; TYR; TYR protein; Tumor rejection antigen AB…

Compound Information

Name chloroform
CAS trichloromethane

Reference List

PubMed Abstract RScore(About this table)
17386749 Campanella L, Lelo D, Martini E, Tomassetti M: Organophosphorus and carbamate pesticide analysis using an inhibition tyrosinase organic phase enzyme sensor; comparison by butyrylcholinesterase+choline oxidase opee and application to natural waters. Anal Chim Acta. 2007 Mar 21;587(1):22-32. Epub 2007 Jan 19.

Since these pesticides are generally much more soluble in chloroform than in water, the present research aimed at analysing this class of pesticides using a tyrosinase inhibition OPEE operating in water-saturated chloroform medium.
84(1,1,1,4) Details
17479420 Devkota KP, Khan MT, Ranjit R, Lannang AM, Samreen, Choudhary MI: Tyrosinase inhibitory and antileishmanial constituents from the rhizomes of Paris polyphylla. Nat Prod Res. 2007 Apr;21(4):321-7.

The chloroform, ethyl acetate, and butanol extracts of the plant were found to have mild to moderate inhibitory potentials against the enzyme tyrosinase.
83(1,1,1,3) Details
18713073 Issa RA, Afifi FU, Amro BI: Studying the anti-tyrosinase effect of Arbutus andrachne L. extracts. Int J Cosmet Sci. 2008 Aug;30(4):271-6.

Five different extracts (chloroform, butanol, ethanol, methanol and water) were prepared from A. andrachne stems and their activities were compared with the selected tyrosinase inhibitors.
35(0,1,1,5) Details
17823775 Yang Z, Yue YJ, Xing M: Tyrosinase activity in ionic liquids. Biotechnol Lett. 2008 Jan;30(1):153-8. Epub 2007 Sep 7.

Activity of mushroom tyrosinase was studied in three ionic liquids, 1-butyl-3-methylimidazolium hexafluorophosphate ([BMIm][PF (6)]), 1-butyl-3-methylimidazolium tetrafluoroborate ([BMIm][BF (4)]) and 1-butyl-3-methylimidazolium methylsulfate ([BMIm][MeSO (4)]), and was compared to that in chloroform.
7(0,0,1,2) Details
17661331 Ullah F, Hussain H, Hussain J, Bukhari IA, Khan MT, Choudhary MI, Gilani AH, Ahmad VU: Tyrosinase inhibitory pentacyclic triterpenes and analgesic and spasmolytic activities of methanol extracts of Rhododendron collettianum. Phytother Res. 2007 Nov;21(11):1076-81.

The methanol extract was then extracted with chloroform.
3(0,0,0,3) Details
17472476 Lee YS, Chang ZQ, Oh BC, Park SC, Shin SR, Kim NW: Antioxidant activity, anti-inflammatory activity, and whitening effects of extracts of Elaeagnus multiflora Thunb. J Med Food. 2007 Mar;10(1):126-33.

In the present study, we analyzed the antioxidant, antiplatelet aggregation, anti-inflammatory, and tyrosinase inhibitory activities of a variety of solvent extracts of Elaeagnus multiflora Thunb. (Family Elaeagnaceae).
Only the chloroform extract (CE) inhibited platelet aggregation, and that was a weak effect with 19.29% inhibition at 250 microg/mL, as compared to controls.
3(0,0,0,3) Details
20213835 Manosroi J, Khositsuntiwong N, Manosroi W, Gotz F, Werner RG, Manosroi A: Enhancement of transdermal absorption, gene expression and stability of tyrosinase plasmid (pMEL34)-loaded elastic cationic niosomes: Potential application in vitiligo treatment. J Pharm Sci. 2010 Mar 8.

The pMEL34 was loaded in elastic cationic niosomes (Tween61/Cholesterol/DDAB at 1:1:0.5 molar ratio) by chloroform film method with sonication and rehydrated with 25% ethanol.
3(0,0,0,3) Details