| 20067886 |
Poplawska B, Bielawska A, Surazynski A, Czarnomysy R, Bielawski K: Novel dinuclear platinum (II) complexes targets NFkappaB signaling pathway to induce apoptosis and inhibit metabolism of MCF-7 breast cancer cells. Folia Histochem Cytobiol. 2009;47(5):S141-6.
Four novel dinuclear platinum (II) complexes of formula [Pt2L4 (berenil) 2] Cl4 (Pt1-Pt4) where L is piperazine (Pt1), 4-picoline (Pt2), 3-picoline (Pt3) or isopropylamine (Pt4) were compared to cisplatin in respect to collagen biosynthesis, beta1- integrin receptor, IGF-I receptor, phosphorylated MAP-kinases (ERK1/ERK2 and p38), phosphorylated Akt kinase expression and appearance of apoptosis in MCF-7 breast cancer cells. |
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