| Name | CYP1A2 |
|---|---|
| Synonyms | CP12; CYP1A2; CYPIA 2; CYPIA2; Cytochrome P450 1A2; Dioxin inducible P3 450; P(3)450; P3 450… |
| Name | piperazine |
|---|---|
| CAS | piperazine |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19904008 | Wojcikowski J, Daniel WA: Perazine at therapeutic drug concentrations inhibits human cytochrome P450 isoenzyme 1A2 (CYP1A2) and metabolism--an in vitro study. Pharmacol Rep. 2009 Sep-Oct;61(5):851-8. The aim of the present study was to estimate the inhibitory effect of perazine, a phenothiazine neuroleptic with piperazine structure in a side chain, on human CYP1A2 activity measured as a rate of 3-N- and 1-N-demethylation. |
38(0,1,1,8) | Details |
| 19589229 | Antia U, Tingle MD, Russell BR: Metabolic interactions with piperazine-based 'party pill' drugs. J Pharm Pharmacol. 2009 Jul;61(7):877-82. CONCLUSIONS: Fluorophenylpiperazine, methoxyphenylpiperazine, chlorophenylpiperazine, methylbenzylpiperazine and methylenedioxybenzylpiperazine had significant inhibitory effects on CYP2D6, CYP1A2, CYP3A4, CYP2C19 and CYP2C9 isoenzymes but each piperazine had a different inhibitory profile. |
32(0,1,1,2) | Details |
| 15056479 | Wojcikowski J, Pichard-Garcia L, Maurel P, Daniel WA: The metabolism of the piperazine-type phenothiazine neuroleptic perazine by the human cytochrome P-450 isoenzymes. Eur Neuropsychopharmacol. 2004 May;14(3):199-208. In human liver microsomes, the formation of perazine metabolites correlated significantly with the level of CYP1A2 and ethoxyrezorufin O-deethylase activity, as well as with the level of CYP3A4 and cyclosporin A oxidase activity. |
4(0,0,0,4) | Details |
| 11393588 | Mihara K, Kondo T, Suzuki A, Yasui-Furukori N, Ono S, Otani K, Kaneko S: Effects of genetic polymorphism of CYP1A2 inducibility on the steady-state plasma concentrations of trazodone and its active metabolite m-chlorophenylpiperazine in depressed Japanese patients. Pharmacol Toxicol. 2001 May;88(5):267-70. |
3(0,0,0,3) | Details |
| 14698036 | Staack RF, Paul LD, Springer D, Kraemer T, Maurer HH: Cytochrome P450 dependent metabolism of the new designer drug 1-(3-trifluoromethylphenyl) piperazine (TFMPP). Biochem Pharmacol. 2004 Jan 15;67(2):235-44. Studies using human CYPs showed that CYP1A2, CYP2D6 and CYP3A4 catalyzed TFMPP hydroxylation, with CYP2D6 being the most important enzyme accounting for about 81% of the net intrinsic clearance, calculated using the relative activity factor approach. |
1(0,0,0,1) | Details |
| 11719709 | Kaneko K, Uchida K, Kobayashi T, Miura K, Tanokura K, Hoshino K, Kato I, Onoue M, Yokokura T: Sex-dependent toxicity of a novel acyl-CoA:cholesterol acyltransferase inhibitor, YIC-C8-434, in relation to sex-specific forms of cytochrome P450 in rats. Toxicol Sci. 2001 Dec;64(2):259-68. Inhibition experiments using anti-rat CYP1A1, CYP1A2, CYP2B1, CYP2C11, CYP2E1, CYP3A2, and CYP4A1 antisera indicated that CYP3A2 played the predominant role in the metabolism of YIC-C8-434 in rats. |
1(0,0,0,1) | Details |
| 20148045 | Antia U: 'Party pill' drugs--BZP and TFMPP. N Z Med J. 2009 Dec 11;122(1307):55-68. Their metabolism involves the hepatic P450 enzymes CYP2D6, CYP1A2 and CYP3A4 resulting in inhibited metabolism of other drugs and medicines, as well as compromised metabolism in poor metabolisers for CYP2D6. |
1(0,0,0,1) | Details |
| 11502731 | Cherstniakova SA, Bi D, Fuller DR, Mojsiak JZ, Collins JM, Cantilena LR: Metabolism of vanoxerine, 1-[2-[bis (4-fluorophenyl) methoxy] ethyl]-4-(3-phenylpropyl) piperazine, by human cytochrome P450 enzymes. Drug Metab Dispos. 2001 Sep;29(9):1216-20. |
0(0,0,0,0) | Details |