Protein Information

Name anticholinesterase
Synonyms Acylcholine acylhydrolase; BCHE; BCHE protein; Butyrylcholine esterase; Butyrylcholinesterase; CHE1; Choline esterase II; Cholinesterase…

Compound Information

Name demeton
CAS

Reference List

PubMed Abstract RScore(About this table)
7237776 Lewis PJ, Lowing RK, Gompertz D: Automated discrete kinetic method for erythrocyte acetylcholinesterase and plasma cholinesterase. Clin Chem. 1981 Jun;27(6):926-9.

To emphasize the need for measuring both erythrocyte acetylcholinesterase and plasma cholinesterase activity in workers exposed to organophosphate pesticides, we present a study of serial activities of both enzymes in a person accidentally exposed to demeton-S-methyl.
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15629114 Fischer S, Arad A, Margalit R: Lipsome-formulated enzymes for organophosphate scavenging: butyrylcholinesterase and Demeton-S. Arch Biochem Biophys. 2005 Feb 1;434(1):108-15.
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7399597 Dikshith TS, Datta KK, Kushwah HS, Chandra P, Raizada RB: Effect of methyl demeton on vital organs & cholinesterase in male rats. Indian J Exp Biol. 1980 Feb;18(2):163-6.
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17582755 Luckarift HR, Greenwald R, Bergin MH, Spain JC, Johnson GR: Biosensor system for continuous monitoring of organophosphate aerosols. Biosens Bioelectron. 2007 Oct 31;23(3):400-6. Epub 2007 May 6.

The enzymes butyrylcholinesterase (BuChE) and organophosphate hydrolase (OPH) are stabilized by encapsulation in biomimetic silica nanoparticles, entrained within a packed bed column.
The system proved suitable for detection of a range of organophosphates including paraoxon, demeton-S and malathion.
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973741 Felsenstein WC, Staiff DC, Miller GC: Acute demeton poisoning in a child. Arch Environ Health. 1976 Sep-Oct;31(5):266-9.

Plasma (pseudo) cholinesterase levels 15 to 41 hours after exposure ranged from 0.24 to 0.48 international units (IU).
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967794 Klose R, Gutensohn G: [Treatment of alkyl phosphate poisoning with purified serum cholinesterase (author's transl)]. Prakt Anaesth. 1976 Feb;11(1):1-7.

A 26-years-old man injected himself intramuscularly with 3.75 gram of demeton methyl in an attempt to commit suicide.
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954759 Okonek S, Boelcke G, Hollmann H: Therapeutic properties.of haemodialysis and blood exchange transfusion in organophosphate poisoning. Eur J Intensive Care Med. 1976;2(1):13-8.

Human blood was contaminated with nitrostigmine, dimethoate and demeton-S-methyl sulfoxide.
The influence of blood exchange transfusion on poison elimination as well as on the cholinesterase activity of blood, brain and muscle was studied in rats poisoned with nitrostigmine.
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19778163 Eyer F, Worek F, Eyer P, Felgenhauer N, Haberkorn M, Zilker T, Thiermann H: Obidoxime in acute organophosphate poisoning: 1 - clinical effectiveness. Clin Toxicol. 2009 Sep;47(8):798-806.


In this article we report clinical findings and activity of cholinesterase in plasma and acetylcholinesterase (AChE) in red blood cells.
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10207609 Worek F, Diepold C, Eyer P: Dimethylphosphoryl-inhibited human cholinesterases: inhibition, reactivation, and aging kinetics. Arch Toxicol. 1999 Feb;73(1):7-14.

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9292288 Thiermann H, Mast U, Klimmek R, Eyer P, Hibler A, Pfab R, Felgenhauer N, Zilker T: Cholinesterase status, pharmacokinetics and laboratory findings during obidoxime therapy in organophosphate poisoned patients. Hum Exp Toxicol. 1997 Aug;16(8):473-80.

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2307312 Clemens GR, Hartnagel RE, Bare JJ, Thyssen JH: Teratological, neurochemical, and postnatal neurobehavioral assessment of METASYSTOX-R, an organophosphate pesticide in the rat. Fundam Appl Toxicol. 1990 Jan;14(1):131-43.


MSR produced a dose-related reduction in maternal plasma (30-72%), red blood cell (18-56%), and brain (21-68%) cholinesterase (ChE) activity, when measured on Day 16 of gestation.
1(0,0,0,1) Details
19778190 Thiermann H, Worek F, Eyer P, Eyer F, Felgenhauer N, Zilker T: Obidoxime in acute organophosphate poisoning: 2 - PK/PD relationships. Clin Toxicol. 2009 Sep;47(8):807-13.


METHODS: We measured the activity of cholinesterase in plasma and AChE in red blood cells (RBC) and related these data with neuromuscular transmission analysis (ulnar nerve stimulation).
1(0,0,0,1) Details
3993886 Kipling RM, Cruickshank AN: Organophosphate insecticide poisoning. Anaesthesia. 1985 Mar;40(3):281-4.


A case of acute poisoning with an organophosphate anticholinesterase insecticide is reported.
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