| Name | PLA2 |
|---|---|
| Synonyms | 85 kDa calcium independent phospholipase A2; PLA 2; PLA2; CaI PLA2; GVI; GVI PLA2; Group VI phospholipase A2; INAD 1… |
| Name | piperazine |
|---|---|
| CAS | piperazine |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 11738488 | Binisti C, Assogba L, Touboul E, Mounier C, Huet J, Ombetta JE, Dong CZ, Redeuilh C, Heymans F, Godfroid JJ: Structure-activity relationships in platelet-activating factor (PAF). 11-From PAF-antagonism to phospholipase A (2) inhibition: syntheses and structure-activity relationships in 1-arylsulfamido-2-alkylpiperazines. Eur J Med Chem. 2001 Oct;36(10):809-28. In addition structure-activity relationships allow new hypothesis on interaction of these piperazine derivatives with the catalytic site of PLA (2) s. |
82(1,1,1,2) | Details |
| 17456042 | Narendra Sharath Chandra JN, Ponnappa KC, Sadashiva CT, Priya BS, Nanda BL, Gowda TV, Vishwanath BS, Rangappa KS: Chemistry and structural evaluation of different phospholipase A2 inhibitors in arachidonic acid pathway mediated inflammation and snake venom toxicity. Curr Top Med Chem. 2007;7(8):787-800. PLA2 inhibitors specific to Group I and II PLA2 isoforms are therapeutically important as anti-inflammatory molecules and against venom toxicity. Among these analogue piperazine derivatives on optimization with respect to hydrophobicity and electronegativity showed inhibition at nanomolar levels. |
5(0,0,0,5) | Details |