| Name | Mu opioid receptor |
|---|---|
| Synonyms | MOR 1; MOR1; Mu opiate receptor; Mu opioid receptor; Mu type opioid receptor; OPRM; OPRM 1; OPRM1… |
| Name | piperazine |
|---|---|
| CAS | piperazine |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15158798 | Bedurftig S, Wunsch B: Chiral, nonracemic (piperazin-2-yl) derivatives with sigma-receptor affinity. Bioorg Med Chem. 2004 Jun 15;12(12):3299-311. In this series the p-methoxybenzyl substituted piperazine 3d reveals the highest sigma1-receptor affinity (Ki=12.4 nM) with selectivity toward sigma2-, -, kappa-opioid, and mu-opioid receptors. |
81(1,1,1,1) | Details |
| 15742360 | D'Antuono M, de Guzman P, Kano T, Avoli M: Ripple activity in the dentate gyrus of dishinibited hippocampus-entorhinal cortex slices. J Neurosci Res. 2005 Apr 1;80(1):92-103. Ripples, which were also recorded in "minislices" only of the dentate gyrus, were unaffected by application of the mu-opioid receptor agonist (D-Ala2-N-Me-Phe,Gly-ol) enkephalin (10 microM; n = 6) or the (NMDA) receptor antagonist 3-(2-carboxy-piperazine-4-yl)-propyl-l-phosphonate (10 microM; n = 5). |
31(0,1,1,1) | Details |
| 11848227 | Sato S, Komoto T, Kanamaru Y, Kawamoto N, Okada T, Kaiho T, Mogi K, Morimoto S, Umehara N, Koda T, Miyashita A, Sakamoto T, Niino Y, Oka T: New mu-opioid receptor agonists with phenoxyacetic acid moiety. Chem Pharm Bull. 2002 Feb;50(2):292-7. New muq-opioid receptor (MOR) agonists containing 4-hydroxypiperidine, piperidine and piperazine moieties were synthesized and evaluated to find a peripheral opioid analgesic. |
1(0,0,0,1) | Details |
| 11300879 | Thomas JB, Herault XM, Rothman RB, Atkinson RN, Burgess JP, Mascarella SW, Dersch CM, Xu H, Flippen-Anderson JL, George CF, Carroll FI: Factors influencing agonist potency and selectivity for the opioid delta receptor are revealed in structure-activity relationship studies of the 4-[(N-substituted-4-piperidinyl) arylamino]-N,N-diethylbenzamides. J Med Chem. 2001 Mar 15;44(6):972-87. Additionally, it was discovered that the somewhat lower mu/delta selectivities observed for the piperidine compounds relative to the piperazine-based ligands appear to arise as a consequence of the carbon- transposition which imparts an overall lower delta and higher mu affinity to the piperidine-based ligands. This is particularly important since analogues of 1, which show both mu- and delta-type activity, are now recognized as important for their strong analgesia and cross-canceling of many of the side effects found in agonists operating exclusively from either the delta or mu opioid receptor. |
1(0,0,0,1) | Details |
| 11605661 | Komoto T, Okada T, Sato S, Niino Y, Oka T, Sakamoto T: New mu-opioid receptor agonists with piperazine moiety. Chem Pharm Bull. 2001 Oct;49(10):1314-20. |
162(2,2,2,2) | Details |