| Name | myoglobin |
|---|---|
| Synonyms | MB; Myoglobin; PVALB; Myoglobins |
| Name | piperazine |
|---|---|
| CAS | piperazine |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 12431046 | Najajreh Y, Perez JM, Navarro-Ranninger C, Gibson D: Novel soluble cationic trans-diaminedichloroplatinum (II) complexes that are active against cisplatin resistant ovarian cancer cell lines. J Med Chem. 2002 Nov 21;45(24):5189-95. The platinum-piperazine complexes bind proteins (ubiquitin and myoglobin) very slowly as compared to cisplatin and to their neutral piperidine analogues. |
81(1,1,1,1) | Details |
| 12459912 | Najajreh Y, Peleg-Shulman T, Moshel O, Farrell N, Gibson D: Ligand effects on the binding of cis- and trans-[PtCl (2) Am (1) Am (2)] to proteins. J Biol Inorg Chem. 2003 Jan;8(1-2):167-75. Epub 2002 Sep 25. As part of a systematic study of the basic principles that govern the formation and reactivity of Pt-protein adducts, we report the effect of substituting the amine ligand of cis- and trans-[PtCl (2)(NH (3))(2)] complexes with bulkier planar aromatic or nonplanar cyclic amine ligands on the binding properties of the complexes to ubiquitin and to horse heart myoglobin. The introduction of a charged piperazine ligand significantly decreased the rate of binding to the protein, possibly owing to electrostatic interactions or -bond formations with the surface of the protein. |
1(0,0,0,1) | Details |