| Name | demethylase |
|---|---|
| Synonyms | DMTase; Demethylase; MBD 2; MBD2; Methyl CpG binding domain protein 2; Methyl CpG binding protein MBD2; NY CO 41; Demethylases… |
| Name | piperazine |
|---|---|
| CAS | piperazine |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19539408 | Che X, Sheng C, Wang W, Cao Y, Xu Y, Ji H, Dong G, Miao Z, Yao J, Zhang W: New azoles with potent antifungal activity: design, synthesis and molecular docking. Eur J Med Chem. 2009 Oct;44(10):4218-26. Epub 2009 May 24. On the basis of the active site of 14alpha-demethylase from Candida albicans (CACYP51), a series of new azoles with substituted-phenoxypropyl piperazine side chains were rational designed and synthesized. |
31(0,1,1,1) | Details |
| 19132812 | Hassold E, Backhaus T: Chronic toxicity of five structurally diverse demethylase-inhibiting fungicides to the crustacean Daphnia magna: a comparative assessment. Environ Toxicol Chem. 2009 Jun;28(6):1218-26. Therefore, we selected a representative of each of the major DMI classes--the piperazine triforine, the pyrimidine fenarimol, the pyrifenox, the prochloraz, and the triazole triadimefon--and comparatively investigated their chronic toxicity to Daphnia magna. |
2(0,0,0,2) | Details |
| 14967005 | Hutzler JM, Steenwyk RC, Smith EB, Walker GS, Wienkers LC: Mechanism-based inactivation of cytochrome P450 2D6 by 1-[(2-ethyl-4-methyl-1H--5-yl) methyl]- 4-[4-(trifluoromethyl)-2-pyridinyl] piperazine: kinetic characterization and evidence for apoprotein adduction. Chem Res Toxicol. 2004 Feb;17(2):174-84. Loss of dextromethorphan O-demethylase activity following coincubation with EMTPP followed pseudo-first-order kinetics and was both - and EMTPP-dependent. |
2(0,0,0,2) | Details |