Protein Information

Name prodynorphin
Synonyms Beta neoendorphin; Beta neoendorphin dynorphin; Beta neoendorphin dynorphin precursor; Dynorphin; Enkephalin B; Leu enkephalin; Leumorphin; PDYN…

Compound Information

Name piperazine
CAS piperazine

Reference List

PubMed Abstract RScore(About this table)
11226394 Romualdi P, D'Addario C, Ferri S, Cox BM, Izenwasser S: Chronic GBR 12909 administration differentially alters prodynorphin gene expression compared to cocaine. Eur J Pharmacol. 2001 Feb 16;413(2-3):207-12.

The effect of the selective dopamine uptake inhibitor 1-[2-[bis (4-flourophenyl) methoxy] ethyl]-4-[3-phenylpropyl] piperazine dihydrochloride (GBR 12909) was examined on prodynorphin gene expression.
36(0,1,1,6) Details
12393064 Hiramatsu M, Hoshino T, Kameyama T, Nabeshima T: Involvement of kappa-opioid and sigma receptors in short-term memory in mice. Eur J Pharmacol. 2002 Oct 18;453(1):91-8.

Kappa-opioid receptor agonists, trans-(+/-)-3,4-dichloro-N-methyl-N-(2-[1-pyrrolidinyl] cyclohexyl) benzeneacetamide methanesulfonate (U-50,488H) and dynorphin A-(1-13), improve impairments of learning and memory in mice and rats. sigma Receptor agonists, (+)-N-allylnormetazocine ((+)-SKF10,047) and 1-(3,4-dimethoxyphenethyl)-4-(3-phenylpropyl) piperazine dihydrochloride (SA4503), also reverse learning and memory impairment in various animal models.
31(0,1,1,1) Details
12360537 Smith LA, Tel BC, Jackson MJ, Hansard MJ, Braceras R, Bonhomme C, Chezaubernard C, Del Signore S, Rose S, Jenner P: Repeated administration of piribedil induces less dyskinesia than L-dopa in MPTP-treated common marmosets: a behavioural and biochemical investigation. Mov Disord. 2002 Sep;17(5):887-901.


Piribedil ([1-(3,4-methylenedioxybenzyl)-4-(2-pyrimidinyl) piperazine]; S 4200) is a dopamine agonist with equal affinity for D (2)/D (3) dopamine receptors effective in treating Parkinson's disease as monotherapy or as an adjunct to levodopa (L-dopa).
0(0,0,0,0) Details