| Name | somatostatin |
|---|---|
| Synonyms | Growth hormone release inhibiting factor; SMST; SST; Somatostatin; Somatostatin precursor; Somatostatins; Somatostatin precursors |
| Name | piperazine |
|---|---|
| CAS | piperazine |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19208473 | Troxler T, Hurth K, Mattes H, Prashad M, Schoeffter P, Langenegger D, Enz A, Hoyer D: Discovery of novel non-peptidic piperazine amide derivatives and their optimization to achiral, easily accessible, potent and selective somatostatin sst1 receptor antagonists. Bioorg Med Chem Lett. 2009 Mar 1;19(5):1305-9. Epub 2009 Jan 27. |
82(1,1,1,2) | Details |
| 15135911 | Hoyer D, Nunn C, Hannon J, Schoeffter P, Feuerbach D, Schuepbach E, Langenegger D, Bouhelal R, Hurth K, Neumann P, Troxler T, Pfaeffli P: SRA880, in vitro characterization of the first non-peptide somatostatin sst (1) receptor antagonist. Neurosci Lett. 2004 May 6;361(1-3):132-5. This report describes the in vitro features of the first somatostatin sst (1) receptor selective non-peptide antagonist, SRA880 ([3R,4aR,10aR]-1,2,3,4,4a,5,10,10a-Octahydro-6-methoxy-1-methyl-benz [g] quinoline-3-carboxylic-acid-4-(4-nitro-phenyl)-piperazine-amide, |
35(0,1,1,5) | Details |
| 18766330 | Marazioti A, Pitychoutis PM, Papadopoulou-Daifoti Z, Spyraki C, Thermos K: Activation of somatostatin receptors in the globus pallidus increases rat locomotor activity and release in the striatum. Psychopharmacology. 2008 Dec;201(3):413-22. Epub 2008 Sep 3. |
9(0,0,0,9) | Details |
| 15778878 | Marazioti A, Kastellakis A, Antoniou K, Papasava D, Thermos K: Somatostatin receptors in the ventral pallidum/substantia innominata modulate rat locomotor activity. Psychopharmacology. 2005 Sep;181(2):319-26. Epub 2005 Oct 14. |
8(0,0,0,8) | Details |
| 11172755 | Inoue T, Wang F, Moriguchi A, Shirakawa K, Matsuoka N, Goto T: FK960, a novel potential anti-dementia drug, enhances high K (+)-evoked release of somatostatin from rat hippocampal slices. Brain Res. 2001 Feb 16;892(1):111-7. We have demonstrated that FK960 [N-(4-acetyl-1-piperazinyl)-p-fluorobenzamide monohydrate], a novel putative anti-dementia drug of piperazine derivative, ameliorates memory deficits in a variety of animal models of dementia in rats and monkeys, and also augments long-term potentiation (LTP) in the mossy fiber-CA3 pathway in guinea-pig hippocampal slices. |
4(0,0,0,4) | Details |
| 12235074 | Theodorou V, Chovet M, Eutamene H, Fargeau H, Dassaud M, Toulouse M, Bihoreau C, Roman FJ, Bueno L: Antidiarrhoeal properties of a novel sigma ligand (JO 2871) on toxigenic diarrhoea in mice: mechanisms of action. Gut. 2002 Oct;51(4):522-8. BMY 14802 (1000 microg/kg orally), a sigma receptor antagonist, or cyclosomatostatin (CSS 1 microg/kg intravenously), a somatostatin antagonist, were given five minutes prior to JO 2871 in LPS, E coli-sta, and C difficile toxin treated mice. |
2(0,0,0,2) | Details |
| 20007849 | Foong JP, Parry LJ, Gwynne RM, Bornstein JC: 5-HT (1A), SST (1), and SST (2) receptors mediate inhibitory postsynaptic potentials in the submucous plexus of the guinea pig ileum. Am J Physiol Gastrointest Liver Physiol. 2010 Mar;298(3):G384-94. Epub 2009 Dec 10. The specific SSTR (2) antagonist CYN 154806 (100 nM) and a specific SSTR (1) antagonist SRA 880 (3 microM) each reduced the amplitude of nonadrenergic IPSPs and hyperpolarizations evoked by somatostatin. |
1(0,0,0,1) | Details |