| Name | transferase |
|---|---|
| Synonyms | 4' phosphopantetheinyl transferase; 4' phosphopantetheinyl transferase; AASD PPT; AASDHPPT; AASDPPT; Alpha aminoadipic semialdehyde dehydrogenase phosphopantetheinyl transferase; Aminoadipate semialdehyde dehydrogenase phosphopantetheinyl transferase; CGI 80… |
| Name | endosulfan |
|---|---|
| CAS | 6,7,8,9,10,10-hexachloro-1,5,5a,6,9,9a-hexahydro-6,9-methano-2,4,3-benzodioxathiepin 3-oxide |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19324396 | Sarma K, Pal AK, Sahu NP, Ayyappan S, Baruah K: Dietary high protein and mitigates endosulfan toxicity in the spotted murrel, Channa punctatus (Bloch, 1793). Sci Total Environ. 2009 Jun 1;407(12):3668-73. Epub 2009 Mar 26. Results indicated significant reduction in the growth performance, survival, and activities of lactate dehydrogenase (liver and muscle), malate dehydrogenase (liver and muscle), enzymes of protein metabolism amino transferase in liver and amino transferase in liver and muscle), acetyl choline esterase (brain), alkaline phosphatase activity (liver), and ATPase (gill) enzymes of group fed control diet and exposed to endosulfan. |
31(0,1,1,1) | Details |
| 2908437 | Blat A, Almar MM, Romero FJ: The effect of two -containing pesticides, fenitrothion and endosulfan, on (GSH) content and on GSH S-transferase and gamma-glutamyl transpeptidase activities in midgut gland of the American red crayfish Procambarus clarkii. Drug Metabol Drug Interact. 1988;6(3-4):383-94. |
7(0,0,1,2) | Details |
| 15259607 | Choudhary N, Sharma M, Verma P, Joshi SC: Hepato and nephrotoxicity in rat exposed to endosulfan. . J Environ Biol. 2003 Jul;24(3):305-8. amino transferase, amino transferase, acid phosphatase, alkaline phosphatase, urea and were increased which clearly showed the hepato and nephrotoxic effect of endosulfan. |
6(0,0,1,1) | Details |
| 12011480 | Wade MG, Parent S, Finnson KW, Foster W, Younglai E, McMahon A, Cyr DG, Hughes C: Thyroid toxicity due to subchronic exposure to a complex mixture of 16 organochlorines, lead, and cadmium. Toxicol Sci. 2002 Jun;67(2):207-18. To investigate the potential effects of a complex, environmentally relevant mixture on the HPT axis, sexually mature male rats were administered a mixture of 16 common organochlorines (dichlorodiphenoxytrichloroethane [DDT], p,p'-dichlorodiphenoxydichloroethylene [p,p'-DDE], hexachlorobenzene [HCB], tetrachlorodibenzo-p-dioxin [TCDD], polychlorinated biphenyls [PCBs], methoxychlor, endosulfan, heptachlor, hexachlorocyclohexane, dieldrin, aldrin, mirex, and several chlorinated benzenes, and metal contaminants [lead, cadmium]). After 70 daily treatments by gavage, endpoints related to circulating thyroid hormone (serum [T (4)], [T (3)], thyroid stimulating hormone [TSH], and serum T (3) uptake [T (3)-up]), thyroid gland histomorphology (thyroid follicle cross sectional area, epithelial height, follicle roundness or aspect ratio, colloid/epithelial ratio) and hepatic metabolism of thyroid hormone (UDP-glucuronyl transferase [UGT] and outer-ring deiodinase [ORD]) were assessed. |
1(0,0,0,1) | Details |
| 11701388 | Bayoumi AE, Garcia-Fernandez AJ, Ordonez C, Perez-Pertejo Y, Cubria JC, Reguera RM, Balana-Fouce R, Ordonez D: Cyclodiene organochlorine insecticide-induced alterations in the -redox cycle in CHO-K1 cells. Comp Biochem Physiol C Toxicol Pharmacol. 2001 Nov;130(3):315-23. The effect of the cyclodiene organochlorine pesticides aldrin, dieldrin and endosulfan was assessed on CHO-K1 cultures at fractions of their lethal doses, determined by the neutral red (NRI) incorporation assay (NRI6.25, NRI12.5 and NRI25). peroxidase, reductase and S-transferase, and total and oxidised were evaluated along the standard growth curve of the cultures. |
2(0,0,0,2) | Details |
| 7900959 | Naqvi SM, Vaishnavi C: Bioaccumulative potential and toxicity of endosulfan insecticide to non-target animals. Comp Biochem Physiol C. 1993 Jul;105(3):347-61. Reproductive toxicity: degenerative changes in the seminiferous epithelium, induction of the rate-limiting enzyme in production (3beta-hydroxysteroid transferase and 17 beta-hydroxysteroid transferase), histological changes in reproductive organs, testicular atrophy and the occurrence of ovarian cysts were noticed in rat. |
1(0,0,0,1) | Details |
| 45318 | Agarwal DK, Seth PK, Gupta PK: Effect of endosulfan on drug metabolizing enzymes and lipid peroxidation in rat. J Environ Sci Health C. 1978;13(1):49-62. There was a marked increase in the activity of aminopyrine-N-demethylase, hydroxylase, amino-transferase and spontaneous lipid peroxidation. |
1(0,0,0,1) | Details |
| 26707 | Agarwal DK, Seth PK, Gupta PK: Effect of endosulfan on drug metabolizing enzymes and lipid peroxidation in rat. J Environ Sci Health C. 1978;13(1):49-62. There was a marked increase in the activity of aminopyrine-N-demethylase, hydroxylase, amino-transferase and spontaneous lipid peroxidation. |
1(0,0,0,1) | Details |
| 1816080 | Singh SK, Pandey RS: potentiates in vivo hepatotoxicity of endosulfan in adult male rats. Indian J Exp Biol. 1991 Nov;29(11):1035-8. A simultaneous induction in the activity of cytosolic GSH-s-transferase was found to be associated with significantly induced -induced microsomal lipid peroxidation. |
1(0,0,0,1) | Details |
| 9075711 | Ramamoorthy K, Wang F, Chen IC, Norris JD, McDonnell DP, Leonard LS, Gaido KW, Bocchinfuso WP, Korach KS, Safe S: Estrogenic activity of a dieldrin/toxaphene mixture in the mouse uterus, MCF-7 human breast cancer cells, and yeast-based estrogen receptor assays: no apparent synergism. Endocrinology. 1997 Apr;138(4):1520-7. Treatment with 10 (-6)-10 (-4) M chlordane, dieldrin, toxaphene, or an equimolar mixture of dieldrin/toxaphene did not induce activity, whereas 10 (-4) M endosulfan caused a 2000-fold increase in beta-gal activity. In parallel studies, estrogenic activities were determined in MCF-7 cells by using a cell proliferation assay and by determining induction of chloramphenicol acetyl transferase (CAT) activity in MCF-7 cells transiently transfected with plasmids containing -responsive 5'-promoter regions from the rat kinase B and human cathepsin D genes. |
1(0,0,0,1) | Details |
| 10771139 | Ait-Aissa S, Porcher J, Arrigo A, Lambre C: Activation of the hsp70 promoter by environmental inorganic and organic chemicals: relationships with cytotoxicity and lipophilicity. Toxicology. 2000 Apr 14;145(2-3):147-57. For this purpose, we used an established HeLa cell line containing the chloramphenicol acetyl transferase (CAT) gene under the control of the hsp70 promoter. Some organochlorine compounds (chlorophenol derivatives, tetrachlorohydroquinone, 3, 4-dichloroaniline, ethyl parathion and 1-chloro-2,4-dinitrobenzene) induced a response, whereas other common halogenated pesticides or aromatic hydrocarbons (e.g. benzo (a) pyrene, 2, 4-dichlorophenoxyacetic acid, endosulfan, diuron, 4-nonylphenol) did not. |
1(0,0,0,1) | Details |