| Name | p38 |
|---|---|
| Synonyms | AIMP 2; p38; AIMP2; JTV 1; JTV1; JTV1 gene; JTV1 protein; Multisynthetase complex auxiliary component p38… |
| Name | piperazine |
|---|---|
| CAS | piperazine |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 20067886 | Poplawska B, Bielawska A, Surazynski A, Czarnomysy R, Bielawski K: Novel dinuclear platinum (II) complexes targets NFkappaB signaling pathway to induce apoptosis and inhibit metabolism of MCF-7 breast cancer cells. Folia Histochem Cytobiol. 2009;47(5):S141-6. Four novel dinuclear platinum (II) complexes of formula [Pt2L4 (berenil) 2] Cl4 (Pt1-Pt4) where L is piperazine (Pt1), 4-picoline (Pt2), 3-picoline (Pt3) or isopropylamine (Pt4) were compared to cisplatin in respect to collagen biosynthesis, beta1- integrin receptor, IGF-I receptor, phosphorylated MAP-kinases (ERK1/ERK2 and p38), phosphorylated Akt kinase expression and appearance of apoptosis in MCF-7 breast cancer cells. |
31(0,1,1,1) | Details |
| 16971122 | Bullington J, Argentieri D, Averill K, Carter D, Cavender D, Fahmy B, Fan X, Hall D, Heintzelman G, Jackson P, Leung WP, Li X, Ling P, Olini G, Razler T, Reuman M, Rupert K, Russell R, Siekierka J, Wadsworth S, Wolff R, Xiang B, Zhang YM: Inhibitors of unactivated p38 MAP kinase. . Bioorg Med Chem Lett. 2006 Dec 1;16(23):6102-6. Epub 2006 Sep 12. The first class of potent p38 kinase inhibitors was the pyridinylimidazole compounds from SKB. |
3(0,0,0,3) | Details |
| 18771755 | Hwang J, Zheng LT, Ock J, Lee MG, Suk K: Anti-inflammatory effects of m-chlorophenylpiperazine in brain glia cells. Int Immunopharmacol. 2008 Dec 10;8(12):1686-94. Epub 2008 Sep 2. In addition, m-CPP inhibited nuclear factor-kappa B activation and phosphorylation of p38 mitogen-activated protein kinase in the LPS-stimulated microglia cells, providing molecular mechanisms of the anti-inflammatory effects. |
1(0,0,0,1) | Details |
| 12354565 | Chen J, Shen C, Meller E: 5-HT1A receptor-mediated regulation of mitogen-activated protein kinase phosphorylation in rat brain. Eur J Pharmacol. 2002 Oct 4;452(2):155-62. The effect of 8-OH-DPAT was blocked by pretreatment with the selective 5-HT (1A) receptor antagonists N-[2-[4-(2-methoxyphenyl)-1-piperazinyl] ethyl]-N-2-pyridinylcyclohexanecar boxamide (WAY 100635), 1-(2-methoxyphenyl)-4-(4-[2-phthalimido] butyl) piperazine (NAN-190) and 4--N-(2-[4-(2-methoxyphenyl) 1-piperazinyl] ethyl)-N-(2-pyridinyl) benz amide dihydrochloride (p-MPPF), but not by the weak partial agonist/antagonist 8-(2-[4-(2-methoxyphenyl)-1-piperazinyl] ethyl)-8-azaspiro (4.5) decane-7,9-d ione dihydrochloride (BMY 7378). |
0(0,0,0,0) | Details |