| Name | acetylcholine receptors (protein family or complex) |
|---|---|
| Synonyms | Acetylcholine receptor; Acetylcholine receptors |
| Name | piperazine |
|---|---|
| CAS | piperazine |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 12190322 | Toma L, Quadrelli P, Bunnelle WH, Anderson DJ, Meyer MD, Cignarella G, Gelain A, Barlocco D: 6-Chloropyridazin-3-yl derivatives active as nicotinic agents: synthesis, binding, and modeling studies. J Med Chem. 2002 Aug 29;45(18):4011-7. 3,8-Diazabicyclo [3.2.1] (1), 2,5-diazabicyclo [2.2.1] heptane (2), piperazine (3), and homopiperazine (4) derivatives, substituted at one atom with the 6-chloro-3-pyridazinyl group while the other atom was either unsubstituted or mono- or dimethylated, were synthesized and tested for their affinity toward the neuronal nicotinic acetylcholine receptors (nAChRs). |
31(0,1,1,1) | Details |
| 13678839 | Harder A, Schmitt-Wrede HP, Krucken J, Marinovski P, Wunderlich F, Willson J, Amliwala K, Holden-Dye L, Walker R: Cyclooctadepsipeptides--an anthelmintically active class of compounds exhibiting a novel mode of action. Int J Antimicrob Agents. 2003 Sep;22(3):318-31. In nematodes, there are five targets for the existing anthelmintics: the nicotinergic acetylcholine receptor which is the target of tetrahydropyrimidines/imidazothiazoles and indirectly that of the acetylcholineesterase inhibitors; the GABA receptor which is the target of piperazine, the -gated chloride channel as the target of the macrocyclic lactones, and beta-tubulin as the target of prebenzimidazoles/benzimidazoles. |
31(0,1,1,1) | Details |
| 12467625 | Chen J, Norrholm S, Dwoskin LP, Crooks PA, Bai D: N,N-disubstituted piperazines: synthesis and affinities at alpha4beta2 (*) and alpha7 (*) neuronal nicotinic acetylcholine receptors. Bioorg Med Chem Lett. 2003 Jan 6;13(1):97-100. Thus, linking together a pi-system and a cyclic amine moiety via a piperazine ring affords compounds with low affinity, but good selectivity for alpha4beta2 (*) nicotinic receptors. |
2(0,0,0,2) | Details |
| 15848206 | Artali R, Bombieri G, Meneghetti F: Docking of 6-chloropyridazin-3-yl derivatives active on nicotinic acetylcholine receptors into molluscan binding protein (AChBP). Farmaco. 2005 Apr;60(4):313-20. The crystal structure of Binding Protein (AChBP), homolog of the ligand binding domain of nAChR, has been used as model for computational investigations on the ligand-receptor interactions of derivatives of 6-chloropyridazine substituted at C3 with 3,8-diazabicyclo [3.2.1] 2,5-diazabicyclo [2.2.1] heptane and with piperazine and homopiperazine, substituted or not at N4. |
1(0,0,0,1) | Details |