| Name | ATPase |
|---|---|
| Synonyms | ATP7A; MK; ATPase; Cation transporting ATPase; ATP7A protein; ATPase Cu(2+) transporting alpha polypeptide; Copper pump 1; Copper transporting ATPase 1… |
| Name | piperazine |
|---|---|
| CAS | piperazine |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15740781 | Shimazaki T, Chaki S: Anxiolytic-like effect of a selective and non-peptidergic melanocortin 4 receptor antagonist, MCL0129, in a social interaction test. Pharmacol Biochem Behav. 2005 Mar;80(3):395-400. Epub 2005 Jan 16. Melanocortins have five receptor subtypes (MC1-MC5). We investigated the involvement of MC4 receptor in a social interaction test, using Ac-[Nle (4),Asp (5),D- (7),Lys (10)] alpha-MSH-(4-10)-NH2 (MT II), an MC4 receptor agonist, and 1-[(S)-2-(4-fluorophenyl)-2-(4-isopropylpiperadin-1-yl) ethyl]-4-[4-(2-meth oxynaphthalen-1-yl) butyl] piperazine (MCL0129), a selective and nonpeptide MC4 receptor antagonist. |
1(0,0,0,1) | Details |
| 15720784 | Iskra-Jopa J, Golembiowska K, Dziubina A, Cybulski M, Duszynska B, Chilmonczyk Z: In-vivo effects of the 1,2,4-piperazine derivatives MM5 and MC1, putative agonists, on and release in rat prefrontal cortex. J Pharm Pharmacol. 2005 Feb;57(2):205-11. |
84(1,1,1,4) | Details |
| 19241538 | Wang LL, Xiong YL: Inhibition of oxidant-induced biochemical changes of pork myofibrillar protein by hydrolyzed potato protein. J Food Sci. 2008 Aug;73(6):C482-7. MPI prepared from pork muscle was suspended (30 mg protein/mL) in 15 mM piperazine-N, N-bis (2-ethane buffer (pH 6.0) with 0, 0.3, 0.75, and 1.5 mg/mL of antioxidative HPP (1-h Alcalase hydrolysate). Changes in oxidized MPI were measured as thiobarbituric acid-reactive substances (TBARS), protein carbonylcontent, Ca- and K-ATPase activities, and ultraviolet (UV) spectra. |
2(0,0,0,2) | Details |
| 16842156 | McDonald E, Jones K, Brough PA, Drysdale MJ, Workman P: Discovery and development of pyrazole-scaffold Hsp90 inhibitors. . Curr Top Med Chem. 2006;6(11):1193-203. Hsp90 has an ATPase domain that is necessary for its Hsp chaperone function, and X-ray crystallography has shown that natural product inhibitors (geldanamycin, radicicol) of Hsp90 function bind to this domain. SAR and X-ray data are summarised for analogues in which the 4-phenyl substituent is replaced by amides or piperazine derivatives. |
2(0,0,0,2) | Details |
| 16756379 | Park D, Xiong YL, Alderton AL, Ooizumi T: Biochemical changes in myofibrillar protein isolates exposed to three oxidizing systems. J Agric Food Chem. 2006 Jun 14;54(12):4445-51. Myofibrillar protein isolate (MPI) prepared from pork serratus ventralis muscle was suspended (30 mg protein/mL) in 15 mM piperazine-N,N-bis (2-ethane buffer (pH 6.0). Changes in oxidized MPI were measured as Ca- and K-ATPase activities, formation of protein carbonyls and 2-thiobarbituric acid-reactive substances (TBARS), loss of protein thermal stability, and protein aggregation. |
2(0,0,0,2) | Details |
| 12538838 | Chaki S, Hirota S, Funakoshi T, Suzuki Y, Suetake S, Okubo T, Ishii T, Nakazato A, Okuyama S: Anxiolytic-like and antidepressant-like activities of MCL0129 (1-[(S)-2-(4-fluorophenyl)-2-(4-isopropylpiperadin-1-yl) ethyl]-4-[4-(2-met hoxynaphthalen-1-yl) butyl] piperazine), a novel and potent nonpeptide antagonist of the melanocortin-4 receptor. J Pharmacol Exp Ther. 2003 Feb;304(2):818-26. MCL0129 inhibited [(125) I][Nle (4)-D- (7)]-alpha-melanocyte-stimulating hormone (alpha-MSH) binding to MC4 receptor with a K (i) value of 7.9 nM, without showing affinity for MC1 and MC3 receptors. |
1(0,0,0,1) | Details |