| Name | ATPase |
|---|---|
| Synonyms | ATP7A; MK; ATPase; Cation transporting ATPase; ATP7A protein; ATPase Cu(2+) transporting alpha polypeptide; Copper pump 1; Copper transporting ATPase 1… |
| Name | endosulfan |
|---|---|
| CAS | 6,7,8,9,10,10-hexachloro-1,5,5a,6,9,9a-hexahydro-6,9-methano-2,4,3-benzodioxathiepin 3-oxide |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 1447481 | Janik F, Wolf HU: The Ca (2+)-transport-ATPase of human erythrocytes as an in vitro toxicity test system--acute effects of some chlorinated compounds. J Appl Toxicol. 1992 Oct;12(5):351-8. Investigations to determine the inhibitory activity on the Ca (2+)-transport-ATPase of human erythrocyte membranes were performed with various compounds of toxicological significance, mostly chlorinated and mainly used as biocides, such as 4-chlorophenol, 2,6-dichlorophenol, 3,4-dichlorophenol, 2,3,4-trichlorophenol, 2,3,4,5-tetrachlorophenol, pentachlorophenol (PCP), captan, folpet, captafol, (+)-camphene, toxaphene, dichlorodiphenyltrichloroethane (DDT), lindane, endrin, dieldrin, alpha-endosulfan, beta-endosulfan, paraquat, diallate, 2,4-dichlorophenoxyacetic acid (2,4-D) and 2,4,5-trichlorophenoxyacetic acid (2,4,5-T). |
34(0,1,1,4) | Details |
| 2531805 | Srikanth NS, Seth PK, Desaiah D: Inhibition of calmodulin-activated Ca2 (-)-ATPase by endosulfan in rat brain. J Toxicol Environ Health. 1989;28(4):473-81. Endosulfan stereoisomer I (E-I) inhibited the activity of calmodulin-dependent Ca2+-ATPase to an extent of 15-55% in a concentration range of 1-20 microM under in vitro conditions without significantly affecting the basal enzyme activity. |
113(1,2,2,3) | Details |
| 219562 | Dalela RC, Bhatnagar MC, Tyagi AK, Verma SR: triphosphatase activity in few tissues of a fresh water teleost, Channa gachua following in vivo exposure to endosulfan. Toxicology. 1978 Dec;11(4):361-8. The marked sensitivity of mitochondrial Mg2+ ATPase to endosulfan is suggestive of the potential for endosulfan to interfere markedly with various energy requiring processes in the fish body. |
38(0,1,2,3) | Details |
| 2157509 | Yadwad VB, Kallapur VL, Basalingappa S: Inhibition of gill Na+ K (+)-ATPase activity in dragonfly larva, Pantala flavesens, by endosulfan. Bull Environ Contam Toxicol. 1990 Apr;44(4):585-9. |
31(0,1,1,1) | Details |
| 18613510 | Ren NQ, Zhang XD, Zhou GH, Chen SJ: [Induced apoptosis and mechanism of endosulfan in mouse germ cells] . Huan Jing Ke Xue. 2008 Feb;29(2):386-90. Endosulfan might enhance concentration in the spermatogenic cells and restrained Na+ K+ -ATPase and Ca2+ Mg2+ -ATPase activities that showed endosulfan might induce spermatogenic cells in the testicle to occur apoptosis (p < 0.01), to cause the function of transporting Ca2+ to be limited, reduce the ability of excluding and send Ca2+ concentration to hoist sustainingly,i.e. overload in the cells. |
31(0,1,1,1) | Details |
| 19324396 | Sarma K, Pal AK, Sahu NP, Ayyappan S, Baruah K: Dietary high protein and mitigates endosulfan toxicity in the spotted murrel, Channa punctatus (Bloch, 1793). Sci Total Environ. 2009 Jun 1;407(12):3668-73. Epub 2009 Mar 26. Results indicated significant reduction in the growth performance, survival, and activities of lactate dehydrogenase (liver and muscle), malate dehydrogenase (liver and muscle), enzymes of protein metabolism amino transferase in liver and amino transferase in liver and muscle), acetyl choline esterase (brain), alkaline phosphatase activity (liver), and ATPase (gill) enzymes of group fed control diet and exposed to endosulfan. |
31(0,1,1,1) | Details |
| 1685416 | Reddy DC, Kalarani V, Davies RW: Tissue ATPase activity and recovery in the freshwater crab Oziotelphusa senex senex exposed to a sublethal concentration of endosulfan for varying periods of time. Comp Biochem Physiol C. 1991;99(3):431-5. |
14(0,0,2,4) | Details |
| 17215890 | Aurade R, Jayalakshmi SK, Sreeramulu K: Stimulatory effect of insecticides on partially purified P-glycoprotein ATPase from the resistant pest Helicoverpa armigera. Biochem Cell Biol. 2006 Dec;84(6):1045-50. The partially purified Ha-Pgp ATPase was reconstituted into proteoliposomes and it was found that some insecticides, namely, monocrotophos, endosulfan, cypermethrin, fenvalerate, and methylparathion, stimulated the ATPase activity. |
9(0,0,1,4) | Details |
| 2975512 | Sharma RM: Effect of endosulfan on triphosphatase (ATPase) activity in liver, kidney, and muscles of Channa gachua. Bull Environ Contam Toxicol. 1988 Sep;41(3):317-23. |
6(0,0,1,1) | Details |
| 17490606 | Sreeramulu K, Liu R, Sharom FJ: Interaction of insecticides with mammalian P-glycoprotein and their effect on its transport function. Biochim Biophys Acta. 2007 Jul;1768(7):1750-7. Epub 2007 Apr 5. We studied the effects of four commonly used insecticides (methylparathion, endosulfan, cypermethrin and fenvalerate) on P-glycoprotein isolated from multidrug-resistant cells. All the pesticides stimulated P-glycoprotein ATPase activity, with maximum stimulation of up to 213% in a detergent-solubilized preparation, and up to 227% in reconstituted liposomes. |
2(0,0,0,2) | Details |
| 17675176 | Glover CN, Petri D, Tollefsen KE, Jorum N, Handy RD, Berntssen MH: Assessing the sensitivity of Atlantic salmon (Salmo salar) to dietary endosulfan exposure using tissue biochemistry and histology. Aquat Toxicol. 2007 Oct 15;84(3):346-55. Epub 2007 Jun 29. Branchial Na (+), K (+)-ATPase activity was significantly reduced at day 14 in the highest exposure group, but returned to control levels by day 35. |
2(0,0,0,2) | Details |
| 6149750 | Dubey RK, Beg MU, Singh J: Effects of endosulfan and its metabolites on rat liver mitochondrial respiration and enzyme activities in vitro. Biochem Pharmacol. 1984 Nov 1;33(21):3405-10. A maximal 25-fold activation of latent Mg2+-ATPase was achieved at a concentration that caused maximal stimulation of state-4 respiration. |
1(0,0,0,1) | Details |
| 18443843 | Aggarwal M, Naraharisetti SB, Sarkar SN, Rao GS, Degen GH, Malik JK: Effects of subchronic coexposure to arsenic and endosulfan on the erythrocytes of broiler chickens: a biochemical study. Arch Environ Contam Toxicol. 2009 Jan;56(1):139-48. Epub 2008 Apr 29. None of the treatments affected the activities of total ATPase and Mg2+-ATPase. |
1(0,0,0,1) | Details |
| 2272657 | Kiran R, Varma MN: Age related toxic effects of endosulfan on certain enzymes of rat erythrocytes. Indian J Exp Biol. 1990 Jul;28(7):694-6. Erythrocyte membrane Na+, K (+)-ATPase and Mg2 (+)-ATPase activities were significantly inhibited in all the age groups of rats. |
1(0,0,0,1) | Details |
| 4257269 | Davis PW, Wedemeyer GA: Na + , K + -activated-ATPase inhibition in rainbow trout: a site for organochlorine pesticide toxicity? Comp Biochem Physiol B. 1971 Nov 15;40(3):823-7. |
1(0,0,0,1) | Details |
| 15454122 | Garg UK, Pal AK, Jha GJ, Jadhao SB: Haemato-biochemical and immuno-pathophysiological effects of chronic toxicity with synthetic pyrethroid, organophosphate and chlorinated pesticides in broiler chicks. Int Immunopharmacol. 2004 Dec 15;4(13):1709-22. Haemato- biochemical and immuno-pathophysiological changes following feeding of broiler chicks with 20 ppm fenvalerate (synthetic pyrethroid, SP), 2 ppm monocrotophos (organophosphate, OP) and 2 ppm endosulfan (chlorinated hydrocarbon, CH) were studied. The total ATPase activity was enhanced (P <0.01) in fenvalerate and monocrotophos than birds in control group. |
1(0,0,0,1) | Details |
| 7900959 | Naqvi SM, Vaishnavi C: Bioaccumulative potential and toxicity of endosulfan insecticide to non-target animals. Comp Biochem Physiol C. 1993 Jul;105(3):347-61. In fish, it causes marked changes in Na and K concentrations, decrease in blood Ca (2+) and Mg levels and inhibits Na, K and Mg-dependent ATPase (in brain). 2. |
1(0,0,0,1) | Details |