Protein Information

Name cytochrome P450 (protein family or complex)
Synonyms cytochrome P450; cytochrome P 450; CYP450; CYP 450

Compound Information

Name natamycin
CAS

Reference List

PubMed Abstract RScore(About this table)
15228385 Mendes MV, Anton N, Martin JF, Aparicio JF: Characterization of the polyene macrolide P450 epoxidase from Streptomyces natalensis that converts de-epoxypimaricin into pimaricin. Biochem J. 2005 Feb 15;386(Pt 1):57-62.


The biosynthesis of the antifungal agent pimaricin by Streptomyces natalensis has been proposed to involve a cytochrome P450 encoded by the gene pimD.
2(0,0,0,2) Details
11451665 Mendes MV, Recio E, Fouces R, Luiten R, Martin JF, Aparicio JF: Engineered biosynthesis of novel polyenes: a pimaricin derivative produced by targeted gene disruption in Streptomyces natalensis. Chem Biol. 2001 Jul;8(7):635-44.


This biologically active product resulted from the phage-mediated targeted disruption of the gene pimD, which encodes the cytochrome P450 epoxidase that converts deepoxypimaricin into pimaricin.
1(0,0,0,1) Details