| Name | p38 |
|---|---|
| Synonyms | AIMP 2; p38; AIMP2; JTV 1; JTV1; JTV1 gene; JTV1 protein; Multisynthetase complex auxiliary component p38… |
| Name | nitrofen |
|---|---|
| CAS | 2,4-dichloro-1-(4-nitrophenoxy)benzene |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17439724 | Tong QS, Zheng LD, Tang ST, Jiang GS, Ruan QL, Zeng FQ, Dong JH: Nitrofen suppresses cell proliferation and promotes mitochondria-mediated apoptosis in type II pneumocytes. Acta Pharmacol Sin. 2007 May;28(5):672-84. Meanwhile, nitrofen strongly activated the p38 mitogen-activated protein kinase (p38-MAPK). |
193(2,3,3,3) | Details |
| 15582350 | Kling DE, Aidlen JT, Fisher JC, Kinane TB, Donahoe PK, Schnitzer JJ: Nitrofen induces a redox-dependent apoptosis associated with increased p38 activity in P19 teratocarcinoma cells. Toxicol In Vitro. 2005 Feb;19(1):1-10. Therefore, nitrofen induces P19 cell apoptosis that is cell-redox-dependent and is associated with increases in p38 activity and ROS and may play a role in nitrofen-mediated birth defects. |
37(0,1,2,2) | Details |
| 16988192 | Nogueira-Silva C, Santos M, Baptista MJ, Moura RS, Correia-Pinto J: IL-6 is constitutively expressed during lung morphogenesis and enhances fetal lung explant branching. Pediatr Res. 2006 Nov;60(5):530-6. Epub 2006 Sep 20. Normal and nitrofen-induced hypoplastic lung explants were cultured with increasing IL-6 doses or IL-6 neutralizing antibodies. IL-6 enhanced p38-MAPK phosphorylation without changing MEK1/2 and JNK pathways. |
2(0,0,0,2) | Details |