Protein Information

Name glycogen phosphorylase
Synonyms Glycogen phosphorylase; MGP; M GP; Muscle glycogen phosphorylase; Myophosphorylase; PYGM; Phos; Muscle glycogen phosphorylases…

Compound Information

Name diazinon
CAS

Reference List

PubMed Abstract RScore(About this table)
17286147 Teimouri F, Amirkabirian N, Esmaily H, Mohammadirad A, Aliahmadi A, Abdollahi M: Alteration of hepatic cells glucose metabolism as a non-cholinergic detoxication mechanism in counteracting diazinon-induced oxidative stress. Hum Exp Toxicol. 2006 Dec;25(12):697-703.

The activities of glycogen phosphorylase (GP), phosphoenolpyruvate carboxykinase (PEPCK), thiobarbituric acid reactive substances (TBARS) and total antioxidant capacity (TAC) were analysed in liver homogenate.
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2818201 Matin MA, Khan SN, Hussain K, Sattar S: Effect of adrenalectomy on diazinon-induced changes in carbohydrate metabolism. Arch Toxicol. 1989;63(5):376-80.

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2344375 Matin MA, Husain K, Khan SN: Modification of diazinon-induced changes in carbohydrate metabolism by adrenalectomy in rats. Biochem Pharmacol. 1990 Jun 1;39(11):1781-6.

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3617100 Husain K, Mirza MA, Matin MA: Convulsions as the etiology of lactic acidosis in acute diazinon toxicity in rats. Toxicol Lett. 1987 Aug;37(3):257-61.

Diazinon, in acute doses (40 mg/kg, i.p.) in rats produced tremors and convulsions with lactic acidosis which was accompanied by depletion of glycogen and activation of glycogen phosphorylase activity in triceps and diaphragm muscles, 2 h after its administration.
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2851382 Husain K, Ansari RA: Influence of cholinergic and adrenergic blocking drugs on hyperglycemia and brain glycogenolysis in diazinon-treated animals. Can J Physiol Pharmacol. 1988 Sep;66(9):1144-7.

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3508478 Matin MA, Husain K: Cerebral glucose and glycogen metabolism in diazinon-treated animals. J Biochem Toxicol. 1987 Fall-Winter;2:265-70.

Glycogen was depleted, but there was an increase in the activities of glycogen phosphorylase, phosphoglucomutase, hexokinase, lactate dehydrogenase, and fructose 1,6 diphosphatase.
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3624768 Matin MA, Husain K: Changes in cerebral glycogenolysis and related enzymes in diazinon treated hyperglycaemic animals. J Appl Toxicol. 1987 Apr;7(2):131-4.

In diazinon-treated hyperglycaemic animals, the glycogen content of the brain was depleted, the activities of glycogen phosphorylase, phosphoglucomutase and hexokinase were significantly increased and the activity of glucose-6-phosphatase remained unchanged.
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20020971 Amirkabirian N, Teimouri F, Esmaily H, Mohammadirad A, Aliahmadi A, Abdollahi M: Protection by pentoxifylline of diazinon-induced toxic stress in rat liver and muscle. Toxicol Mech Methods. 2007;17(4):215-21.

Administration of diazinon increased blood glucose, hepatic glycogen phosphorylase (GP), and phosphoenol pyruvate carboxykinase (PEPCK) by 160.65%, 117.2%, and 93.5%, respectively, while it decreased plasma cholinesterase (ChE) by 53.82%.
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2092650 Matin MA, Sattar S, Husain K: The role of adrenals in diazinon-induced changes in carbohydrate metabolism in rats. Arh Hig Rada Toksikol. 1990 Dec;41(4):347-56.

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