Protein Information

Name IL 1beta
Synonyms Catabolin; IL 1; IL 1 beta; IL 1B; IL1 beta; IL1B; IL1F2; Interleukin 1…

Compound Information

Name cresol
CAS methylphenol

Reference List

PubMed Abstract RScore(About this table)
16954166 Faure V, Cerini C, Paul P, Berland Y, Dignat-George F, Brunet P: The uremic solute p-cresol decreases leukocyte transendothelial migration in vitro. Int Immunol. 2006 Oct;18(10):1453-9. Epub 2006 Sep 5.

In this study, we examined whether the uremic solute para-cresol (p-cresol), at concentrations similar to those found in patients, alters leukocyte transmigration in vitro.
We found that p-cresol significantly inhibited monocyte THP-1 cell line and PBMCs transmigration across IL-1beta-stimulated human umbilical vein endothelial cell (HUVEC) in a static two-compartment model.
3(0,0,0,3) Details
11673462 Girard T, Cavagna D, Padovan E, Spagnoli G, Urwyler A, Zorzato F, Treves S: B-lymphocytes from malignant hyperthermia-susceptible patients have an increased sensitivity to skeletal muscle ryanodine receptor activators. J Biol Chem. 2001 Dec 21;276(51):48077-82. Epub 2001 Oct 22.


Our results show that (i) Epstein-Barr virus-immortalized B-cells from MH-susceptible individuals carrying the V2168M RYR1 gene mutation were more sensitive to the RYR activator 4-chloro-m-cresol and (ii) their peripheral blood leukocytes produce more interleukin (IL)-1beta after treatment with the RYR activators caffeine and 4-chloro-m-cresol, compared with cells from healthy controls.
2(0,0,0,2) Details
12427124 Dou L, Cerini C, Brunet P, Guilianelli C, Moal V, Grau G, De Smet R, Vanholder R, Sampol J, Berland Y: P-cresol, a uremic toxin, decreases endothelial cell response to inflammatory cytokines. Kidney Int. 2002 Dec;62(6):1999-2009.


METHODS: Human umbilical vein endothelial cells (HUVEC) were incubated with p-cresol in the presence or absence of tumor necrosis factor (TNF) or interleukin-1beta (IL-1beta).
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9523304 Remmele RL Jr, Nightlinger NS, Srinivasan S, Gombotz WR: Interleukin-1 receptor (IL-1R) liquid formulation development using differential scanning calorimetry. Pharm Res. 1998 Feb;15(2):200-8.

1(0,0,0,1) Details