| Name | demethylase |
|---|---|
| Synonyms | DMTase; Demethylase; MBD 2; MBD2; Methyl CpG binding domain protein 2; Methyl CpG binding protein MBD2; NY CO 41; Demethylases… |
| Name | griseofulvin |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 12678289 | Haisah AH, Elsheikh HA, Khairi HM, Salam Abdullah A, Rajion MA: Effect of griseofulvin on the toxicity of signal grass (Brachiaria decumbens) in sheep. Vet Hum Toxicol. 2003 Mar;45(2):68-71. Griseofulvin oral administration of 5 mg/kg body weight for 5 consecutive days every other week for 10 w increased the hepatic concentration of cytochrome P-450 and the activity of phase II drug metabolizing enzymes -glucuronyltransferase and glutathione-S-transferase) while it decreased the hepatic and increased the renal activity of phase I enzymes aminopyrine-N-demethylase and -4-hydroxylase. |
31(0,1,1,1) | Details |
| 10599028 | Matsumura Y, Yokota M, Yoshioka H, Shibata S, Ida S, Takiguchi Y: Acute effects of griseofulvin on the pharmacokinetics and pharmacodynamics of in rats. J Int Med Res. 1999 Jul-Aug;27(4):167-75. Total cytochrome P-450, and the activities of aminopyrine N-demethylase, p-hydroxylase and 7-ethoxycoumarin O-deethylase, after repeated administration of griseofulvin (100 mg/kg orally daily for 5 days) were examined. |
6(0,0,1,1) | Details |
| 10556648 | Farombi EO, Akinloye O, Akinmoladun CO, Emerole GO: Hepatic drug metabolizing enzyme induction and serum triacylglycerol elevation in rats treated with chlordiazepoxide, griseofulvin, rifampicin and phenytoin. Clin Chim Acta. 1999 Nov;289(1-2):1-10. Five days intraperitoneal administration of rats with chlordiazepoxide (0.4 mg/kg), griseofulvin (7 mg/kg), rifampicin (8. 6 mg/kg), phenytoin (4.3 mg/kg) and phenobarbitone (1.4 mg/kg; an established inducer of microsomal enzymes) caused a significant increase in serum triacylglycerol (P <0.001) and the activities of hydroxylase, aminopyrine N-demethylase and p-nitroanisole O-demethylase (P <0.001). |
13(0,0,2,3) | Details |
| 7388813 | Denk H, Abdelfattah-Gad M, Eckerstorfer R, Talcott RE: Microsomal mixed-function oxidase and activities of some related enzymes in hyperplastic nodules induced by long-term griseofulvin administration in mouse liver. Cancer Res. 1980 Jul;40(7):2568-73. Despite a decrease in microsomal cytochrome P-450 in hyperplastic nodules, aminopyrine N-demethylase was at control levels. |
1(0,0,0,1) | Details |