| Name | alanine aminotransferase |
|---|---|
| Synonyms | AAT1; AAT1; GPT; ALT 1; ALT1; Alanine aminotransferase; Alanine aminotransferase 1; GPT 1… |
| Name | diazinon |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 7815357 | Jeong TC, Jordan SD, Matulka RA, Stanulis ED, Kaminski EJ, Holsapple MP: Role of metabolism by esterase and cytochrome P-450 in cocaine-induced suppression of the antibody response. J Pharmacol Exp Ther. 1995 Jan;272(1):407-16. Spleen and thymus weights were decreased significantly and serum glutamate-pyruvate transaminase activities were elevated dramatically when cocaine and diazinon were administered together. beta-Ionone was administered s.c. for 7 consecutive days and the P-450 activities were determined 3 days after the last administration. beta-Ionone induced cocaine N-demethylation, which is the first step in the activation of cocaine to the metabolites capable of producing hepatotoxicity, as well as P-450IA1- and P-450IIB1-specific monooxygenases. |
32(0,1,1,2) | Details |
| 9435205 | Ndikum-Moffor FM, Schoeb TR, Roberts SM: Liver toxicity from norcocaine an N-oxidative metabolite of cocaine. J Pharmacol Exp Ther. 1998 Jan;284(1):413-9. In this study mice were administered norcocaine i.p., and hepatotoxicity was assessed using serum alanine aminotransferase activities and microscopic examination of liver tissue. Pretreatment with diazinon, an esterase inhibitor, increased norcocaine -induced liver damage, whereas each of the P450 inhibitors SKF 525A, cimetidine, troleandomycin, ketaconazole and chloramphenicol significantly diminished norcocaine hepatotoxicity. |
2(0,0,0,2) | Details |
| 15925023 | Kalender S, Ogutcu A, Uzunhisarcikli M, Acikgoz F, Durak D, Ulusoy Y, Kalender Y: Diazinon-induced hepatotoxicity and protective effect of on some biochemical indices and ultrastructural changes. Toxicology. 2005 Aug 1;211(3):197-206. Epub 2005 Apr 19. Biochemical indices in serum [total protein, albumin, alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), total triglyceride and low density lipoprotein (VLDL- and ultrastructural changes were investigated at the end of the 1st, 4th and 7th weeks comparatively with control group (n=8). |
1(0,0,0,1) | Details |
| 12739815 | Hanna LS, Medhat AM, Abdel-Menem HA: Biochemical changes after subchronic and chronic interaction of Schistosoma mansoni infection in Swiss albino mice with two specific compounds. J Egypt Soc Parasitol. 2003 Apr;33(1):245-60. Effects of diazinon (DZN) and/or praziquantel (PZQ) on the levels of plasma (T3), (T4), activities of brain acetylcholinesterase (AchE) and liver alanine aminotransferase (ALT) in addition to blood (GSH) in healthy and S.m. infected mice were investigated after 9 and 17 weeks of either infection or intoxication with DZN. |
6(0,0,1,1) | Details |