Protein Information

Name growth associated protein 43
Synonyms Axonal membrane protein GAP 43; B 50; Calmodulin binding protein P 57; GAP43; Growth associated protein 43; Nerve growth related peptide GAP43; Neural phosphoprotein B 50; Neuromodulin…

Compound Information

Name diazinon
CAS

Reference List

PubMed Abstract RScore(About this table)
19596371 Harris W, Sachana M, Flaskos J, Hargreaves AJ: Neuroprotection from diazinon-induced toxicity in differentiating murine N2a neuroblastoma cells. Neurotoxicology. 2009 Nov;30(6):958-64. Epub 2009 Jul 9.

Furthermore, a significant recovery was also observed in the reduced levels of neurofilament heavy chain (NFH), heat shock protein-70 (HSP-70) and growth-associated protein-43 (GAP-43) observed as a result of diazinon treatment in the absence of conditioned medium, as seen by densitometric analysis of Western blots of cell lysates probed with monoclonal antibodies N52, BRM-22 and GAP-7B10.
31(0,1,1,1) Details
18633600 Sidiropoulou E, Sachana M, Flaskos J, Harris W, Hargreaves AJ, Woldehiwet Z: Diazinon oxon affects the differentiation of mouse N2a neuroblastoma cells. Arch Toxicol. 2009 Apr;83(4):373-80. Epub 2008 Jul 17.

By contrast, treatment of N2a cells with 1-10 microM DZO resulted in marked reductions in the expression of the axon growth-associated protein GAP-43.
1(0,0,0,1) Details