| 16153748 |
Glanzel M, Bultmann R, Starke K, Frahm AW: Structure-activity relationships of novel P2-receptor antagonists structurally related to Reactive Blue 2. Eur J Med Chem. 2005 Dec;40(12):1262-76. Epub 2005 Sep 8.
In the present study we have pharmacologically evaluated a series of 15 synthesized and re-evaluated four commercially obtained and chromatographically purified RB 2 type anthraquinone derivatives on contractions of the rat vas deferens (RVD) elicited by alpha,beta-methylene ATP (alpha,beta-meATP), mediated by P2X1-receptors, and relaxations of the carbachol-precontracted guinea-pig taenia coli (GPTC) elicited by adenosine 5'-O-(2-thiodiphosphate) (ADPbetaS), mediated by P2Y1-like receptors. |
82(1,1,1,2) |
Details |