| Name | protein kinase A (protein family or complex) |
|---|---|
| Synonyms | Protein kinase A; cAMP dependent protein kinase; cAMP dependent protein kinases |
| Name | anthraquinone |
|---|---|
| CAS | 9,10-anthracenedione |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 1466788 | Jinsart W, Ternai B, Polya GM: Inhibition of myosin light chain kinase, cAMP-dependent protein kinase, protein kinase C and of plant Ca (2+)-dependent protein kinase by anthraquinones. Biol Chem Hoppe Seyler. 1992 Sep;373(9):903-10. A range of anthraquinone derivatives inhibits the catalytic subunit of cAMP-dependent protein kinase (cAK). |
82(1,1,1,2) | Details |
| 7582818 | Zhao WQ, Polya GM, Wang BH, Gibbs ME, Sedman GL, Ng KT: Inhibitors of cAMP-dependent protein kinase impair long-term memory formation in day-old chicks. Neurobiol Learn Mem. 1995 Sep;64(2):106-18. Neither anthraquinone nor the anthraquinone derivative anthraflavic acid, which have little effect on protein kinase A activity, affected memory retention. |
3(0,0,0,3) | Details |
| 19409890 | Xu L, Ting-Lou, Lv N, Zhu X, Chen Y, Yang J: Emodin augments activated chloride channel in colonic smooth muscle cells by Gi/Go protein. Eur J Pharmacol. 2009 Aug 1;615(1-3):171-6. Epub 2009 May 3. Gi/Go protein inhibits protein kinase A (PKA) and protein kinase C (PKC), and PKA and PKC reduced ClCA currents. Emodin is a natural anthraquinone in rhubarb. |
2(0,0,0,2) | Details |
| 7547985 | Faltynek CR, Schroeder J, Mauvais P, Miller D, Wang S, Murphy D, Lehr R, Kelley M, Maycock A, Michne W, et al.: Damnacanthal is a highly potent, selective inhibitor of p56lck kinase activity. Biochemistry. 1995 Sep 26;34(38):12404-10. Damnacanthal, an anthraquinone isolated from a plant extract, was found to be a potent, selective inhibitor of p56lck kinase activity. Damnacanthal had > 100-fold selectivity for p56lck over the serine/threonine kinases, protein kinase A and protein kinase C, and > 40-fold selectivity for p56lck over four receptor tyrosine kinases. |
1(0,0,0,1) | Details |
| 12794753 | Yeh FT, Wu CH, Lee HZ: Signaling pathway for aloe-emodin-induced apoptosis in human H460 lung nonsmall carcinoma cell. Int J Cancer. 2003 Aug 10;106(1):26-33. Aloe-emodin (1,8-dihydroxy-3-(hydroxymethyl)-anthraquinone) is an active component from the root and rhizome of Rheum palmatum that has been reported to exhibit antitumor effects through an unknown mechanism. Aloe-emodin (40 microM)-induced apoptosis of H460 cells involves modulation of cAMP-dependent protein kinase, protein kinase C, Bcl-2, caspase-3 and p38 protein expression. |
2(0,0,0,2) | Details |
| 10083837 | Yim H, Lee YH, Lee CH, Lee SK: Emodin, an anthraquinone derivative isolated from the rhizomes of Rheum palmatum, selectively inhibits the activity of casein kinase II as a competitive inhibitor. Planta Med. 1999 Feb;65(1):9-13. We measured IC50 values for emodin on the activities of several Ser/Thr protein kinases, including cAMP-dependent protein kinase (PKA), protein kinase C (PKC), cdc2, casein kinases I (CKI) and CKII. |
1(0,0,0,1) | Details |