| Name | caspase 3 |
|---|---|
| Synonyms | Apopain; CASP 3; CASP3; CPP 32; CPP32; CPP32B; Caspase 3; Caspase 3 precursor… |
| Name | anthraquinone |
|---|---|
| CAS | 9,10-anthracenedione |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16215684 | Koceva-Chyla A, Jedrzejczak M, Skierski J, Kania K, Jozwiak Z: Mechanisms of induction of apoptosis by anthraquinone anticancer drugs aclarubicin and mitoxantrone in comparison with doxorubicin: relation to drug cytotoxicity and caspase-3 activation. Apoptosis. 2005 Dec;10(6):1497-514. |
33(0,1,1,3) | Details |
| 19744477 | Lai JM, Chang JT, Wen CL, Hsu SL: Emodin induces a reactive species-dependent and ATM-p53-Bax mediated cytotoxicity in lung cancer cells. Eur J Pharmacol. 2009 Nov 25;623(1-3):1-9. Epub 2009 Sep 8. Emodin (1,3,8-trihydroxy-6-methyl-anthraquinone), a natural anthraquinone compound isolated from the rhizome of rhubarb, has been reported to suppress tumor growth in many clinical situations. Co-treating cells with either a p53 inhibitor or respectively knocking down the expression of p53 and Bax by shRNA extensively diminished emodin-induced cell viability, caspase 3 activation and the release of cytochrome c from the mitochondria, indicating the crucial role for p53/Bax in emodin-mediated cytotoxicity. |
1(0,0,0,1) | Details |
| 18035333 | Hsiao CJ, Li TK, Chan YL, Hsin LW, Liao CH, Lee CH, Lyu PC, Guh JH: WRC-213, an -conjugated mitoxantrone derivative, displays anticancer activity with reduced cardiotoxicity and drug resistance: identification of topoisomerase II inhibition and apoptotic machinery in prostate cancers. Biochem Pharmacol. 2008 Feb 15;75(4):847-56. Epub 2007 Oct 22. Several l- and d-form amino acids were introduced into the anthraquinone skeleton and numerous derivatives were synthesized for the evaluation of anticancer activity. After the checkpoint arrest of the cell-cycle, WRC-213 induced the mitochondria-mediated intrinsic apoptotic pathway, including Mcl-1 cleavage, Bcl-2 down-regulation and activation of caspase-9/caspase-3 cascades. |
1(0,0,0,1) | Details |
| 15037204 | Perchellet EM, Wang Y, Weber RL, Sperfslage BJ, Lou K, Crossland J, Hua DH, Perchellet JP: Synthetic 1,4-anthracenedione analogs induce cytochrome c release, caspase-9, -3, and -8 activities, poly (ADP- polymerase-1 cleavage and internucleosomal DNA fragmentation in HL-60 cells by a mechanism which involves caspase-2 activation but not Fas signaling. Biochem Pharmacol. 2004 Feb 1;67(3):523-37. Synthetic analogs of 1,4-anthraquinone (AQ code number), a compound that mimics the antiproliferative effects of daunorubicin (daunomycin) in the nanomolar range in vitro but has the advantage of blocking nucleoside transport and retaining its efficacy in multidrug-resistant tumor cells, were tested for their ability to induce apoptosis in the HL-60 cell system. In accord with the fact that the caspases 9 and 3 cascade is responsible for PARP-1 cleavage, the activities of initiator caspase-9 and effector caspase-3 are induced by AQ9 in the same time- and concentration-dependent manners and to the same maximal degrees in both the HL-60-S and multidrug-resistant HL-60-RV cell lines. |
1(0,0,0,1) | Details |
| 18566240 | Yan Y, Su X, Liang Y, Zhang J, Shi C, Lu Y, Gu L, Fu L: Emodin azide methyl anthraquinone derivative triggers mitochondrial-dependent cell apoptosis involving in caspase-8-mediated Bid cleavage. Mol Cancer Ther. 2008 Jun;7(6):1688-97. Moreover, this apoptotic induction was associated with a collapse of the mitochondrial membrane potential and activated caspases aspartase) cascade involving in caspase-8, caspase-9, caspase-3, and poly (ADP- polymerase cleavage in a concentration-dependent manner. |
1(0,0,0,1) | Details |
| 18789614 | Wang C, Jiang Z, Yao J, Wu X, Sun L, Liu C, Duan W, Yan M, Sun L, Liu J, Zhang L: Participation of cathepsin B in emodin-induced apoptosis in HK-2 Cells. Toxicol Lett. 2008 Oct 1;181(3):196-204. Epub 2008 Sep 11. Emodin (1,3,8-trihydroxy-6-methyl-anthraquinone) and rhein (4,5-dihydroxyanthraquinone-2-carboxyl acid) are two main active compounds in total rhubarb anthraquinones (TRAs), which showed nephrotoxicity in Sprague Dawley (S.D.) rats in our previous study. The ratio of hypodiploid cells and the activity of caspase 3 protease were also detected. |
2(0,0,0,2) | Details |
| 12794753 | Yeh FT, Wu CH, Lee HZ: Signaling pathway for aloe-emodin-induced apoptosis in human H460 lung nonsmall carcinoma cell. Int J Cancer. 2003 Aug 10;106(1):26-33. Aloe-emodin (1,8-dihydroxy-3-(hydroxymethyl)-anthraquinone) is an active component from the root and rhizome of Rheum palmatum that has been reported to exhibit antitumor effects through an unknown mechanism. Aloe-emodin (40 microM)-induced apoptosis of H460 cells involves modulation of cAMP-dependent protein kinase, protein kinase C, Bcl-2, caspase-3 and p38 protein expression. |
2(0,0,0,2) | Details |
| 11730720 | Lee HZ, Hsu SL, Liu MC, Wu CH: Effects and mechanisms of aloe-emodin on cell death in human lung squamous cell carcinoma. Eur J Pharmacol. 2001 Nov 23;431(3):287-95. Aloe-emodin (1,8-dihydroxy-3-(hydroxymethyl)-anthraquinone) is an active component from the root and rhizome of Rheum palmatum. Results demonstrated that the activation of caspase-3, caspase-8, and caspase-9 is an important determinant of apoptotic death induced by aloe-emodin. |
1(0,0,0,1) | Details |
| 20128807 | Xie G, Zhu X, Li Q, Gu M, He Z, Wu J, Li J, Lin Y, Li M, She Z, Yuan J: SZ-685C, a marine anthraquinone, is a potent inducer of apoptosis with anticancer activity by suppression of the Akt/FOXO pathway. Br J Pharmacol. 2010 Jan 28. SZ-685C had a direct apoptosis-inducing effect through both the extrinsic and intrinsic apoptotic pathways, as shown by activation of caspase-8 and 9 as well as effector caspase-3 and poly (ADP- polymerase. |
1(0,0,0,1) | Details |
| 19857484 | Chun-Guang W, Jun-Qing Y, Bei-Zhong L, Dan-Ting J, Chong W, Liang Z, Dan Z, Yan W: Anti-tumor activity of emodin against human chronic myelocytic leukemia K562 cell lines in vitro and in vivo. Eur J Pharmacol. 2010 Feb 10;627(1-3):33-41. Epub 2009 Oct 24. Emodin (1,3,8-trihydroxy-6-methyl-anthraquinone), a natural anthraquinone derivative isolated from Rheum palmatum L, has been reported to exhibit anti-cancer effect on several human cancers such as liver cancers and lung cancers. Moreover, activations of caspase-3, -8 and -9 were demonstrated in vitro and in vivo. |
1(0,0,0,1) | Details |
| 17637488 | Chen SH, Lin KY, Chang CC, Fang CL, Lin CP: Aloe-emodin-induced apoptosis in human gastric carcinoma cells. Food Chem Toxicol. 2007 Nov;45(11):2296-303. Epub 2007 Jun 12. The purpose of this study was to investigate the anticancer effect of aloe-emodin, an anthraquinone compound present in the leaves of Aloe vera, on two distinct human gastric carcinoma cell lines, AGS and NCI-N87. Aloe-emodin caused the release of apoptosis-inducing factor and cytochrome c from mitochondria, followed by the activation of caspase-3, leading to nuclear shrinkage and apoptosis. |
1(0,0,0,1) | Details |
| 18711776 | Shi P, Huang Z, Chen G: Rhein induces apoptosis and cell cycle arrest in human hepatocellular carcinoma BEL-7402 cells. Am J Chin Med. 2008;36(4):805-13. Rhein, an anthraquinone derivative of rhubarb, inhibits the proliferation of various human cancer cells. Additionally, after rhein treatment, expression levels of c-Myc gene were decreased, while those of caspase-3 gene were increased in a dose-dependent manner by using real-time PCR assay. |
1(0,0,0,1) | Details |