| Name | activator protein 1 |
|---|---|
| Synonyms | AP1; Activator protein 1; JUN; Proto oncogene c jun; Protooncogene c jun; Transcription factor AP 1; V jun avian sarcoma virus 17 oncogene homolog; c Jun… |
| Name | anthraquinone |
|---|---|
| CAS | 9,10-anthracenedione |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 9711216 | Goto M, Masegi M, Yamauchi T, Chiba K, Kuboi Y, Harada K, Naruse N: K1115 A, a new anthraquinone derivative that inhibits the binding of activator protein-1 (AP-1) to its recognition sites. J Antibiot. 1998 Jun;51(6):539-44. |
82(1,1,1,2) | Details |
| 9711217 | Naruse N, Goto M, Watanabe Y, Terasawa T, Dobashi K: K1115 A, a new anthraquinone that inhibits the binding of activator protein-1 (AP-1) to its recognition sites. J Antibiot. 1998 Jun;51(6):545-52. |
82(1,1,1,2) | Details |
| 14729614 | Yi J, Yang J, He R, Gao F, Sang H, Tang X, Ye RD: Emodin enhances arsenic trioxide-induced apoptosis via generation of reactive species and inhibition of survival signaling. Cancer Res. 2004 Jan 1;64(1):108-16. Emodin, a natural anthraquinone derivative, was selected because its semiquinone structure is likely to increase the generation of intracellular ROS. ROS generation was increased, and activation of nuclear factor kappaB and activator protein 1 was suppressed by coadministration. |
2(0,0,0,2) | Details |
| 16959273 | Lee J, Jung E, Lee J, Huh S, Hwang CH, Lee HY, Kim EJ, Cheon JM, Hyun CG, Kim YS, Park D: Emodin inhibits TNF alpha-induced MMP-1 expression through suppression of activator protein-1 (AP-1). Life Sci. 2006 Nov 25;79(26):2480-5. Epub 2006 Aug 17. In this study, we found that emodin, an anthraquinone which has been isolated from the rhizome of Rheum palmatum, significantly inhibited TNF alpha-induced MMP-1 gene expression in a concentration-dependent manner. |
1(0,0,0,1) | Details |