| Name | casein kinase II |
|---|---|
| Synonyms | CK II; CK2 catalytic subunit alpha; CK2A1; CKII; CKII alpha; CKIIa; CKIIalpha; CSNK2A1… |
| Name | anthraquinone |
|---|---|
| CAS | 9,10-anthracenedione |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17018259 | Olsen BB, Bjorling-Poulsen M, Guerra B: Emodin negatively affects the phosphoinositide 3-kinase/AKT signalling pathway: a study on its mechanism of action. Int J Biochem Cell Biol. 2007;39(1):227-37. Epub 2006 Aug 30. Emodin is a natural anthraquinone derivative that exhibits anti-proliferative effects in various cancer cell lines by efficient induction of apoptosis. Previous published results indicated that treatment of cells with inhibitors of protein kinase CK2, such as emodin, induces apoptosis and that the anti-apoptotic effect of CK2 is partially mediated by target phosphorylation and up-regulation of AKT by CK2. |
1(0,0,0,1) | Details |
| 1295884 | Takeuchi N, Nakamura T, Takeuchi F, Hashimoto E, Yamamura H: Inhibitory effect of mitoxantrone on activity of protein kinase C and growth of HL60 cells. J Biochem. 1992 Dec;112(6):762-7. Mitoxantrone, a new anthraquinone, showed inhibitory an effect on protein kinase C (PKC) activity. |
0(0,0,0,0) | Details |
| 10083837 | Yim H, Lee YH, Lee CH, Lee SK: Emodin, an anthraquinone derivative isolated from the rhizomes of Rheum palmatum, selectively inhibits the activity of casein kinase II as a competitive inhibitor. Planta Med. 1999 Feb;65(1):9-13. |
166(2,2,2,6) | Details |
| 19432557 | Cozza G, Mazzorana M, Papinutto E, Bain J, Elliott M, di Maira G, Gianoncelli A, Pagano MA, Sarno S, Ruzzene M, Battistutta R, Meggio F, Moro S, Zagotto G, Pinna LA: Quinalizarin as a potent, selective and cell-permeable inhibitor of protein kinase CK2. Biochem J. 2009 Jul 15;421(3):387-95. Emodin (1,3,8-trihydroxy-6-methyl-anthraquinone) is a moderately potent and poorly selective inhibitor of protein kinase CK2, one of the most pleiotropic serine/threonine protein kinases, implicated in neoplasia and in other global diseases. |
82(1,1,1,2) | Details |
| 12419810 | De Moliner E, Moro S, Sarno S, Zagotto G, Zanotti G, Pinna LA, Battistutta R: Inhibition of protein kinase CK2 by anthraquinone-related compounds. J Biol Chem. 2003 Jan 17;278(3):1831-6. Epub 2002 Nov 4. |
81(1,1,1,1) | Details |
| 17637488 | Chen SH, Lin KY, Chang CC, Fang CL, Lin CP: Aloe-emodin-induced apoptosis in human gastric carcinoma cells. Food Chem Toxicol. 2007 Nov;45(11):2296-303. Epub 2007 Jun 12. The purpose of this study was to investigate the anticancer effect of aloe-emodin, an anthraquinone compound present in the leaves of Aloe vera, on two distinct human gastric carcinoma cell lines, AGS and NCI-N87. In addition, exposure to aloe-emodin suppressed the casein kinase II activity in a time-dependent manner and was accompanied by a reduced phosphorylation of Bid, a downstream substrate of casein kinase II and a pro-apoptotic molecule. |
1(0,0,0,1) | Details |