Protein Information

Name MR 1
Synonyms AWQG2491; MR1; PDC; BRP17; Brain protein 17; DYT 8; DYT8; FKSG19…

Compound Information

Name anthraquinone
CAS 9,10-anthracenedione

Reference List

PubMed Abstract RScore(About this table)
11133454 Myers JM, Myers CR: Role for outer membrane cytochromes OmcA and OmcB of Shewanella putrefaciens MR-1 in reduction of manganese dioxide. Appl Environ Microbiol. 2001 Jan;67(1):260-9.

The omcA mutant (OMCA1) resembled MR-1 in its growth on trimethylamine N-oxide (TMAO), dimethyl sulfoxide, nitrate, fumarate, thiosulfate, and tetrathionate and its reduction of nitrate, nitrite, ferric citrate, FeOOH, and anthraquinone-2,6-disulfonic acid.
36(0,1,1,6) Details
15345428 Myers CR, Myers JM: Shewanella oneidensis MR-1 restores menaquinone synthesis to a menaquinone-negative mutant. Appl Environ Microbiol. 2004 Sep;70(9):5415-25.

The mechanisms underlying the use of insoluble electron acceptors by metal-reducing bacteria, such as Shewanella oneidensis MR-1, are currently under intensive study.
While MR-1 is able to release a substance that restores the ability of a menaquinone (MK)-negative mutant, CMA-1, to reduce the humic acid analog anthraquinone-2,6-disulfonate (AQDS), cross-feeding experiments conducted here showed that the substance released by MR-1 restores the growth of CMA-1 on several soluble electron acceptors.
3(0,0,0,3) Details
15995227 Bencharit S, Ward MJ: Chemotactic responses to metals and anaerobic electron acceptors in Shewanella oneidensis MR-1. J Bacteriol. 2005 Jul;187(14):5049-53.

Cells were also shown to respond to another unusual electron acceptor, the humic acid analog anthraquinone-2,6-disulfonate.
2(0,0,0,2) Details
20018675 Harris HW, El-Naggar MY, Bretschger O, Ward MJ, Romine MF, Obraztsova AY, Nealson KH: Electrokinesis is a microbial behavior that requires extracellular electron transport. Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):326-31. Epub 2009 Dec 14.

This behavior was initially observed as a dramatic increase in cell swimming speed during reduction of solid MnO (2) particles by the dissimilatory metal-reducing bacterium Shewanella oneidensis MR-1.
In contrast, the addition of 1 mM 9,10-anthraquinone-2,6-disulfonic acid, a soluble electron shuttle, led to increases in motility in the entire population.
1(0,0,0,1) Details
11872737 Shyu JB, Lies DP, Newman DK: Protective role of tolC in efflux of the electron shuttle anthraquinone-2,6-disulfonate. J Bacteriol. 2002 Mar;184(6):1806-10.

Here we provide genetic evidence that AQDS enters Shewanella oneidensis strain MR-1 and causes cell death if it accumulates past a critical concentration.
1(0,0,0,1) Details
12732551 Saltikov CW, Cifuentes A, Venkateswaran K, Newman DK: The ars detoxification system is advantageous but not required for As (V) respiration by the genetically tractable Shewanella species strain ANA-3. Appl Environ Microbiol. 2003 May;69(5):2800-9.

ANA-3 uses a wide variety of terminal electron acceptors, including oxygen, soluble ferric iron, oxides of iron and manganese, nitrate, fumarate, the humic acid functional analog 2,6-anthraquinone disulfonate, and thiosulfate.
ANA-3 possesses an ars operon (arsDABC) that allows it to resist high levels of As (III); this operon also confers resistance to the As-sensitive strains Shewanella oneidensis MR-1 and Escherichia coli AW3110.
1(0,0,0,1) Details