| Name | C13 |
|---|---|
| Synonyms | C13; FAM48A; FP757; P38IP; Protein FAM48A; Transcription factor (p38 interacting protein); bA421P11.4; p38 interacting protein… |
| Name | anthraquinone |
|---|---|
| CAS | 9,10-anthracenedione |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16382174 | Slupe A, Williams B, Larson C, Lee LM, Primbs T, Bruesch AJ, Bjorklund C, Warner DL, Peloquin J, Shadle SE, Gambliel HA, Cusack BJ, Olson RD, Charlier HA Jr: Reduction of 13-deoxydoxorubicin and daunorubicinol anthraquinones by human carbonyl reductase. Cardiovasc Toxicol. 2005 Fall;5(4):365-76. Steady-state kinetic studies were done with several anthraquinone-containing compounds, including 13-deoxydoxorubicin and daunorubicinol, which lack the C13 carbonyl, thus unmasking the anthraquinone for study. k (cat) and k (cat)/K (m) values for 13-deoxydoxorubicin and daunorubicinol were nearly identical, indicating that that the efficiency of reduction was unaffected by the differences at the C13 position. k (cat) and k (cat)/K (m) values were much smaller for the analogs than for the parent compounds, suggesting that the C13 carbonyl is preferred as a substrate over the |
82(1,1,1,2) | Details |
| 12884955 | Watts P, Kittakoop P, Veeranondha S, Wanasith S, Thongwichian R, Saisaha P, Intamas S, Hywel-Jones NL: Cytotoxicity against insect cells of entomopathogenic fungi of the genera Hypocrella (anamorph Aschersonia): possible agents for biological control. Mycol Res. 2003 May;107(Pt 5):581-6. Extracts from entomopathogenic fungi of the genus Hypocrella (7 species) and its anamorph Aschersonia (11 species) were screened for cytotoxicity to Sf9 and C6/36 insect cells and L929, BHK (21) C13 and HepG2 mammalian cells. Bioassay-guided fractionation of the cell extract of the fungus A. samoensis BCC 1393 led to the identification of two known anthraquinone dimers, (+) rugulosin (1) and skyrin (2) which showed selective toxicity towards insect cells. (+) Rugulosin (1) and skyrin (2) exhibited strong cytotoxic activity against the insect cell line Sf9 with respective ID50 values of 1.2 and 9.6 microg ml (-1), but showed weak activity toward mammalian cells. |
1(0,0,0,1) | Details |