| Name | estrogen receptor |
|---|---|
| Synonyms | ER; ERA; ER alpha; ERalpha; ESR; ESR 1; ESR1; ESRA… |
| Name | anthraquinone |
|---|---|
| CAS | 9,10-anthracenedione |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 10931852 | Marti T, Hu Z, Pohl NL, Shah AN, Khosla C: Cloning, nucleotide sequence, and heterologous expression of the biosynthetic gene cluster for R1128, a non-steroidal estrogen receptor antagonist. J Biol Chem. 2000 Oct 27;275(43):33443-8. R1128 substances are anthraquinone natural products that were previously reported as non-steroidal estrogen receptor antagonists with in vitro and in vivo potency approaching that of tamoxifen. |
32(0,1,1,2) | Details |
| 8360101 | Hori Y, Abe Y, Nishimura M, Goto T, Okuhara M, Kohsaka M: R1128 substances, novel non-steroidal estrogen-receptor antagonists produced by a Streptomyces. J Antibiot. 1993 Jul;46(7):1069-75. |
3(0,0,0,3) | Details |
| 8360100 | Hori Y, Takase S, Shigematsu N, Goto T, Okuhara M, Kohsaka M: R1128 substances, novel non-steroidal estrogen-receptor antagonists produced by a Streptomyces. J Antibiot. 1993 Jul;46(7):1063-8. |
2(0,0,0,2) | Details |
| 8360099 | Hori Y, Abe Y, Ezaki M, Goto T, Okuhara M, Kohsaka M: R1128 substances, novel non-steroidal estrogen-receptor antagonists produced by a Streptomyces. J Antibiot. 1993 Jul;46(7):1055-62. |
2(0,0,0,2) | Details |
| 14966533 | Tang Y, Lee TS, Khosla C: Engineered biosynthesis of regioselectively modified aromatic polyketides using bimodular polyketide synthases. PLoS Biol. 2004 Feb;2(2):E31. Epub 2004 Feb 17. Based upon these findings, hybrid PKSs were engineered to synthesize new anthraquinone antibiotics with predictable functional group modifications. Although the biosynthesis of most aromatic polyketide backbones is initiated through decarboxylation of a malonyl building block (which results in an group), some polyketides, such as the estrogen receptor antagonist R1128, are derived from nonacetate primers. |
1(0,0,0,1) | Details |
| 11764156 | Machala M, Ciganek M, Blaha L, Minksova K, Vondrack J: Aryl hydrocarbon receptor-mediated and estrogenic activities of oxygenated polycyclic aromatic hydrocarbons and azaarenes originally identified in extracts of river sediments. Environ Toxicol Chem. 2001 Dec;20(12):2736-43. In the present study, we have identified 9-fluorenone, anthrone, anthraquinone, benzanthrone, benz [a] anthracene-7,12-dione, benz [c] acridine, and dibenz [a,h] acridine as prevalent oxy-PAHs and azaarenes found in river sediments. |
0(0,0,0,0) | Details |