| Name | p56lck |
|---|---|
| Synonyms | LCK; LSK; Lck; Lymphocyte cell specific protein tyrosine kinase; Lymphocyte specific protein tyrosine kinase; Oncogene LCK; P56 LCK; Protein tyrosine kinase… |
| Name | anthraquinone |
|---|---|
| CAS | 9,10-anthracenedione |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 7547985 | Faltynek CR, Schroeder J, Mauvais P, Miller D, Wang S, Murphy D, Lehr R, Kelley M, Maycock A, Michne W, et al.: Damnacanthal is a highly potent, selective inhibitor of p56lck kinase activity. Biochemistry. 1995 Sep 26;34(38):12404-10. Damnacanthal, an anthraquinone isolated from a plant extract, was found to be a potent, selective inhibitor of p56lck kinase activity. |
86(1,1,1,6) | Details |
| 10050753 | Hiwasa T, Arase Y, Chen Z, Kita K, Umezawa K, Ito H, Suzuki N: Stimulation of ultraviolet-induced apoptosis of human fibroblast UVr-1 cells by kinase inhibitors. FEBS Lett. 1999 Feb 12;444(2-3):173-6. Damnacanthal is an anthraquinone compound isolated from the root of Morinda citrifolia and was reported to have a potent inhibitory activity towards kinases such as Lck, Src, Lyn and EGF receptor. |
81(1,1,1,1) | Details |
| 1517743 | Jayasuriya H, Koonchanok NM, Geahlen RL, McLaughlin JL, Chang CJ: Emodin, a protein tyrosine kinase inhibitor from Polygonum cuspidatum. J Nat Prod. 1992 May;55(5):696-8. Bioassay-directed fractionation of a Chinese medicinal plant, Polygonum cuspidatum (Polygonaceae), has led to the discovery of an anthraquinone, emodin [1], as a strong inhibitor of a protein tyrosine kinase (p56lck) partially purified from bovine thymus. |
81(1,1,1,1) | Details |