| Name | caspases (protein family or complex) |
|---|---|
| Synonyms | caspase; caspases |
| Name | anthraquinone |
|---|---|
| CAS | 9,10-anthracenedione |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16162972 | Wang Y, Perchellet EM, Ward MM, Lou K, Hua DH, Perchellet JP: Rapid collapse of mitochondrial transmembrane potential in HL-60 cells and isolated mitochondria treated with anti-tumor 1,4-anthracenediones. Anticancer Drugs. 2005 Oct;16(9):953-67. Since synthetic analogs of 1,4-anthraquinone (AQ code number), such as AQ8, AQ9 and AQ10, can trigger cytochrome c release without caspase activation and retain their ability to induce apoptosis in multidrug-resistant (MDR) tumor cells, fluorescent probes of transmembrane potential have been used to determine whether these anti-tumor compounds might directly target mitochondria in cell and cell-free systems to cause the collapse of mitochondrial membrane potential (/Deltapsim) that is linked to permeability transition pore (PTP) opening. |
81(1,1,1,1) | Details |
| 17912452 | Perchellet EM, Wang Y, Lou K, Zhao H, Battina SK, Hua DH, Perchellet JP: Novel substituted 1,4-anthracenediones with antitumor activity directly induce permeability transition in isolated mitochondria. Int J Oncol. 2007 Nov;31(5):1231-41. Synthetic analogs of 1,4-anthraquinone (AQ code number), which block nucleoside transport, decrease DNA, RNA and protein syntheses, trigger cytochrome c release without caspase activation, induce apoptotic DNA fragmentation and inhibit the proliferation of wild-type and multidrug resistant tumor cells in the nM range in vitro, rapidly cause the collapse of mitochondrial transmembrane potential in cell and cell-free systems. |
81(1,1,1,1) | Details |
| 19414420 | Lai WW, Yang JS, Lai KC, Kuo CL, Hsu CK, Wang CK, Chang CY, Lin JJ, Tang NY, Chen PY, Huang WW, Chung JG: Rhein induced apoptosis through the endoplasmic reticulum stress, caspase- and mitochondria-dependent pathways in SCC-4 human tongue squamous cancer cells. In Vivo. 2009 Mar-Apr;23(2):309-16. Rhein, an anthraquinone compound, can be found in the rhizome of rhubarb, a traditional Chinese medicine herb showing antitumor activity. |
2(0,0,0,2) | Details |
| 15037204 | Perchellet EM, Wang Y, Weber RL, Sperfslage BJ, Lou K, Crossland J, Hua DH, Perchellet JP: Synthetic 1,4-anthracenedione analogs induce cytochrome c release, caspase-9, -3, and -8 activities, poly (ADP- polymerase-1 cleavage and internucleosomal DNA fragmentation in HL-60 cells by a mechanism which involves caspase-2 activation but not Fas signaling. Biochem Pharmacol. 2004 Feb 1;67(3):523-37. Synthetic analogs of 1,4-anthraquinone (AQ code number), a compound that mimics the antiproliferative effects of daunorubicin (daunomycin) in the nanomolar range in vitro but has the advantage of blocking nucleoside transport and retaining its efficacy in multidrug-resistant tumor cells, were tested for their ability to induce apoptosis in the HL-60 cell system. In accord with the fact that the caspases 9 and 3 cascade is responsible for PARP-1 cleavage, the activities of initiator caspase-9 and effector caspase-3 are induced by AQ9 in the same time- and concentration-dependent manners and to the same maximal degrees in both the HL-60-S and multidrug-resistant HL-60-RV cell lines. |
2(0,0,0,2) | Details |
| 15941563 | Su YT, Chang HL, Shyue SK, Hsu SL: Emodin induces apoptosis in human lung adenocarcinoma cells through a reactive species-dependent mitochondrial signaling pathway. Biochem Pharmacol. 2005 Jul 15;70(2):229-41. Emodin, a natural anthraquinone derivative isolated from Rheum palmatum L., has been reported to exhibit anti-cancer effect on several human cancers such as liver cancers and lung cancers. Ectopic expression of Bcl-2, or treatment with aurintricarboxylic acid, or caspase inhibitors markedly blocked emodin-induced apoptosis. |
2(0,0,0,2) | Details |
| 14522581 | Lin S, Fujii M, Hou DX: Rhein induces apoptosis in HL-60 cells via reactive species-independent mitochondrial death pathway. Arch Biochem Biophys. 2003 Oct 15;418(2):99-107. Rhein is an anthraquinone compound enriched in the rhizome of rhubarb, a traditional Chinese medicine herb showing anti-tumor promotion function. In this study, we first reported that rhein could induce apoptosis in human promyelocytic leukemia cells (HL-60), characterized by caspase activation, poly (ADP) polymerase (PARP) cleavage, and DNA fragmentation. |
1(0,0,0,1) | Details |
| 20128807 | Xie G, Zhu X, Li Q, Gu M, He Z, Wu J, Li J, Lin Y, Li M, She Z, Yuan J: SZ-685C, a marine anthraquinone, is a potent inducer of apoptosis with anticancer activity by suppression of the Akt/FOXO pathway. Br J Pharmacol. 2010 Jan 28. SZ-685C-induced apoptosis was assessed by Annexin V-fluorescein isothiocyanate/propidium iodide staining, terminal deoxynucleotidyl transferase-mediated nick end labelling assay and analysis of caspase activation. |
1(0,0,0,1) | Details |
| 18566240 | Yan Y, Su X, Liang Y, Zhang J, Shi C, Lu Y, Gu L, Fu L: Emodin azide methyl anthraquinone derivative triggers mitochondrial-dependent cell apoptosis involving in caspase-8-mediated Bid cleavage. Mol Cancer Ther. 2008 Jun;7(6):1688-97. Moreover, this apoptotic induction was associated with a collapse of the mitochondrial membrane potential and activated caspases aspartase) cascade involving in caspase-8, caspase-9, caspase-3, and poly (ADP- polymerase cleavage in a concentration-dependent manner. |
1(0,0,0,1) | Details |
| 20169580 | Lu CC, Yang JS, Huang AC, Hsia TC, Chou ST, Kuo CL, Lu HF, Lee TH, Wood WG, Chung JG: Chrysophanol induces necrosis through the production of ROS and alteration of ATP levels in J5 human liver cancer cells. Mol Nutr Food Res. 2010 Feb 18. Anthraquinone compounds have been shown to induce apoptosis in different cancer cell types. Non-apoptotic cell death was induced by chrysophanol in J5 cells and was characterized by caspase independence, delayed externalization of and plasma membrane disruption. |
1(0,0,0,1) | Details |
| 15544921 | Yang J, Li H, Chen YY, Wang XJ, Shi GY, Hu QS, Kang XL, Lu Y, Tang XM, Guo QS, Yi J: Anthraquinones sensitize tumor cells to arsenic cytotoxicity in vitro and in vivo via reactive species-mediated dual regulation of apoptosis. Free Radic Biol Med. 2004 Dec 15;37(12):2027-41. Our previous studies showed that a naphthoquinone and an anthraquinone (emodin) displayed the capability of producing ROS and facilitating arsenic cytotoxicity in both leukemia and solid tumor cell lines. The combination of emodin and arsenic promoted the major apoptotic signaling events, i.e., the collapse of the mitochondrial transmembrane potential, the release of cytochrome c, and the activation of caspases 9 and 3. |
1(0,0,0,1) | Details |