| Name | lactate dehydrogenase (protein family or complex) |
|---|---|
| Synonyms | LDH; lactate dehydrogenase; lactate dehydrogenases |
| Name | anthraquinone |
|---|---|
| CAS | 9,10-anthracenedione |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 9792515 | Bohacova V, Docolomansky P, Breier A, Gemeiner P, Ziegelhoffer A: Interaction of lactate dehydrogenase with anthraquinone dyes: characterization of ligands for dye-ligand chromatography. J Chromatogr B Biomed Sci Appl. 1998 Sep 11;715(1):273-81. |
82(1,1,1,2) | Details |
| 376530 | Beissner RS, Rudolph FB: Effect of anthraquinone dyes and evaluation of the kinetic mechanism of yeast phosphoglycerate kinase. J Biol Chem. 1979 Jul 25;254(14):6273-7. Cibacron Blue 3G-A (CB3G-A, I) was investigated as a ternary complex analogue of lactate dehydrogenase and phosphoglycerate kinase as had been suggested earlier (Stellwagen, E. (1977) Accts. |
1(0,0,0,1) | Details |
| 19067753 | Bhadauria M, Nirala SK, Shrivastava S, Sharma A, Johri S, Chandan BK, Singh B, Saxena AK, Shukla S: Emodin reverses CCl induced hepatic cytochrome P450 (CYP) enzymatic and ultrastructural changes: The in vivo evidence. Hepatol Res. 2009 Mar;39(3):290-300. Epub 2008 Dec 2. Aim: The curative effect of emodin (1,3,8-trihydroxy-6-methyl anthraquinone), an active compound of the plant species Ventilago maderaspatana Gaertn, was evaluated against carbon tetrachloride (CCl (4)) induced hepatic cytochrome P450 (CYP) enzymatic and ultrastructural alterations in rats. Results: The CCl (4) induced-toxic effects were observed with sharp elevation in the release of serum transaminases, alkaline phosphatase, lactate dehydrogenase and gamma-glutamyl transpeptidase. |
1(0,0,0,1) | Details |
| 15905960 | Mijatovic S, Maksimovic-Ivanic D, Radovic J, Miljkovic D, Kaludjerovic GN, Sabo TJ, Trajkovic V: Aloe emodin decreases the ERK-dependent anticancer activity of cisplatin. . Cell Mol Life Sci. 2005 Jun;62(11):1275-82. The present study describes the ability of an anthraquinone derivative aloe emodin (AE) to reduce the cytotoxic activity of the platinum (II)-based anticancer agent cisplatin toward murine L929 fibrosarcoma and C6 glioma cell lines. The protective effect of AE was demonstrated by MTT and crystal violet assays for cell viability, and involved supression of cisplatin-induced apoptosis and necrosis, as assessed by lactate dehydrogenase release and flow cytometric analysis of DNA fragmentation or exposure. |
1(0,0,0,1) | Details |
| 20169580 | Lu CC, Yang JS, Huang AC, Hsia TC, Chou ST, Kuo CL, Lu HF, Lee TH, Wood WG, Chung JG: Chrysophanol induces necrosis through the production of ROS and alteration of ATP levels in J5 human liver cancer cells. Mol Nutr Food Res. 2010 Feb 18. Anthraquinone compounds have been shown to induce apoptosis in different cancer cell types. However, reductions in levels and increases in lactate dehydrogenase activity indicated that chrysophanol stimulated necrotic cell death. |
1(0,0,0,1) | Details |
| 19800773 | Bhadauria M: Dose-dependent hepatoprotective effect of emodin against -induced acute damage in rats. Exp Toxicol Pathol. 2009 Oct 2. Protective effect of emodin (1,3,8-trihydroxy-6-methyl anthraquinone), an active compound of Ventilago madraspatana Gaertn., was evaluated against -induced biochemical and histological alterations in rats. (2g/kg, po) administration caused significant elevation in the release of serum transaminases, alkaline phosphatase, lactate dehydrogenase, serum and serum protein with concomitant decrease in hemoglobin and blood sugar after 24h of its administration. |
1(0,0,0,1) | Details |
| 10099612 | Labrou NE, Eliopoulos E, Clonis YD: Molecular modeling for the design of a biomimetic chimeric ligand. Biotechnol Bioeng. 1999 May 5;63(3):322-32. Application to the purification of bovine heart L-lactate dehydrogenase.. This ligand is an anthraquinone monochlorotriazinyl dye comprising two moieties: (a) the ketocarboxyl biomimetic moiety, 2-(4-aminophenyl)-ethyloxamic acid, linked on the monochlorotriazine ring, mimicking the natural substrate of LDH, and (b) the anthraquinone chromophore moiety, linked also on the same monochlorotriazine ring via a diaminobenzenesulfonate group, acting as pseudomimetic of the cofactor NAD+. |
1(0,0,0,1) | Details |