| Name | ERK1 |
|---|---|
| Synonyms | ERK 1; ERK1; ERT 2; ERT2; Extracellular signal regulated kinase 1; Extracellular signal related kinase 1b; Extracellular signal related kinase 1c; HS44KDAP… |
| Name | anthraquinone |
|---|---|
| CAS | 9,10-anthracenedione |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19505457 | Chen RS, Jhan JY, Su YJ, Lee WT, Cheng CM, Ciou SC, Lin ST, Chuang SM, Ko JC, Lin YW: Emodin enhances gefitinib-induced cytotoxicity via Rad51 downregulation and ERK1/2 inactivation. Exp Cell Res. 2009 Sep 10;315(15):2658-72. Epub 2009 Jun 6. Emodin, a kinase inhibitor, is a natural anthraquinone derivative found in the roots and rhizomes of numerous plants. |
3(0,0,0,3) | Details |
| 19799875 | Ko JC, Su YJ, Lin ST, Jhan JY, Ciou SC, Cheng CM, Lin YW: Suppression of ERCC1 and Rad51 expression through ERK1/2 inactivation is essential in emodin-mediated cytotoxicity in human non-small cell lung cancer cells. Biochem Pharmacol. 2010 Feb 15;79(4):655-64. Epub . Emodin, a kinase inhibitor, is a natural anthraquinone derivative found in the roots and rhizomes of numerous plants. |
2(0,0,0,2) | Details |
| 17056031 | Kaneshiro T, Morioka T, Inamine M, Kinjo T, Arakaki J, Chiba I, Sunagawa N, Suzui M, Yoshimi N: Anthraquinone derivative emodin inhibits tumor-associated angiogenesis through inhibition of extracellular signal-regulated kinase 1/2 phosphorylation. Eur J Pharmacol. 2006 Dec 28;553(1-3):46-53. Epub 2006 Sep 23. |
82(1,1,1,2) | Details |
| 20042515 | Su YJ, Tsai MS, Kuo YH, Chiu YF, Cheng CM, Lin ST, Lin YW: Role of Rad51 down-regulation and extracellular signal-regulated kinases 1 and 2 inactivation in emodin and mitomycin C-induced synergistic cytotoxicity in human non-small-cell lung cancer cells. Mol Pharmacol. 2010 Apr;77(4):633-43. Epub 2009 Dec 30. Emodin (1,3,8-trihydroxy-6-methyl-anthraquinone) is a natural anthraquinone derivative found in the roots and rhizomes of numerous plants. Our previous studies have shown that the mitogen-activated protein kinase kinase (MKK) 1/2-extracellular signal-regulated kinase (ERK) 1/2 signal pathway maintains the expression of Rad51. |
5(0,0,0,5) | Details |
| 19962780 | Ko JC, Su YJ, Lin ST, Jhan JY, Ciou SC, Cheng CM, Chiu YF, Kuo YH, Tsai MS, Lin YW: Emodin enhances cisplatin-induced cytotoxicity via down-regulation of ERCC1 and inactivation of ERK1/2. Lung Cancer. 2009 Dec 3. Emodin, a kinase inhibitor, is a natural anthraquinone derivative found in the roots and rhizomes of numerous plants; it exhibits an anticancer effect on many malignancies. |
4(0,0,0,4) | Details |
| 15843167 | Abdelmohsen K, von Montfort C, Stuhlmann D, Gerber PA, Decking UK, Sies H, Klotz LO: Doxorubicin induces EGF receptor-dependent downregulation of gap junctional intercellular communication in rat liver epithelial cells. Biol Chem. 2005 Mar;386(3):217-23. Exposure of rat liver epithelial cells to doxorubicin, an anthraquinone derivative widely employed in cancer chemotherapy, led to a dose-dependent decrease in gap junctional intercellular communication (GJC). Doxorubicin-induced loss of GJC was mediated by activation of extracellular signal-regulated kinase (ERK)-1 and ERK-2, as demonstrated using inhibitors of ERK activation. |
1(0,0,0,1) | Details |
| 15747063 | Mijatovic S, Maksimovic-Ivanic D, Radovic J, Miljkovic Dj, Harhaji Lj, Vuckovic O, Stosic-Grujicic S, Mostarica Stojkovic M, Trajkovic V: Anti-glioma action of aloe emodin: the role of ERK inhibition. . Cell Mol Life Sci. 2005 Mar;62(5):589-98. The effect of aloe emodin (AE), a herbal anthraquinone derivative, on the rat C6 glioma cell line was investigated. |
0(0,0,0,0) | Details |