| Name | telomerase reverse transcriptase |
|---|---|
| Synonyms | ABG deleted variant of telomerase reverse transcriptase; EST 2; EST2; HEST 2; HEST2; TCS 1; TCS1; TERT… |
| Name | anthraquinone |
|---|---|
| CAS | 9,10-anthracenedione |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 12852760 | Huang HS, Chiou JF, Fong Y, Hou CC, Lu YC, Wang JY, Shih JW, Pan YR, Lin JJ: Activation of human telomerase reverse transcriptase expression by some new symmetrical bis-substituted derivatives of the anthraquinone. J Med Chem. 2003 Jul 17;46(15):3300-7. |
82(1,1,1,2) | Details |
| 18571928 | Huang HS, Huang KF, Li CL, Huang YY, Chiang YH, Huang FC, Lin JJ: Synthesis, human telomerase inhibition and anti-proliferative studies of a series of 2,7-bis-substituted amido-anthraquinone derivatives. Bioorg Med Chem. 2008 Jul 15;16(14):6976-86. Epub 2008 Jun 2. They were evaluated for their effects on telomerase activity, hTERT expression, cell proliferations, and cytotoxicity. |
2(0,0,0,2) | Details |
| 17268103 | Huang HS, Chen IB, Huang KF, Lu WC, Shieh FY, Huang YY, Huang FC, Lin JJ: Synthesis and human telomerase inhibition of a series of regioisomeric disubstituted amidoanthraquinones. Chem Pharm Bull. 2007 Feb;55(2):284-92. These results greatly expand the potential of tricyclic anthraquinone pharmacophore in preventive and/or curative therapy. Expression of the telomerase catalytic component, the human telomerase reverse transcriptase (hTERT), is believed to be controlled primarily at the level of transcription. |
2(0,0,0,2) | Details |
| 15698759 | Huang HS, Chou CL, Guo CL, Yuan CL, Lu YC, Shieh FY, Lin JJ: Human telomerase inhibition and cytotoxicity of regioisomeric disubstituted amidoanthraquinones and aminoanthraquinones. Bioorg Med Chem. 2005 Mar 1;13(5):1435-44. The present study details the effects on human telomerase of these new classes of 1,4- and 1,5-difunctionalized tricyclic anthraquinone compounds. We have used cytotoxicity assay, reporter SEAP assay to monitor the hTERT expression, and TRAP-G4 assay to measure the relative activity of these compounds, and have examined how the attached substituents affect their ability to influence telomerase. |
1(0,0,0,1) | Details |