Protein Information

Name NMDA receptors (protein family or complex)
Synonyms Glutamate [NMDA] receptor; Glutamate [NMDA] receptors; N methyl D aspartate receptor; N methyl D aspartate receptors; NMDA receptor; NMDA receptors

Compound Information

Name anthraquinone
CAS 9,10-anthracenedione

Reference List

PubMed Abstract RScore(About this table)
17404801 Kashiwagi K, Williams K, Igarashi K: Anthraquinone polyamines: novel channel blockers of N-methyl-D-aspartate receptors. Amino Acids. 2007 Aug;33(2):299-304. Epub 2007 Apr 4.

Anthraquinone polyamines block NMDA receptors with some selectivity compared to other glutamate receptors.
89(1,1,2,4) Details
17050777 Jin L, Sugiyama H, Takigawa M, Katagiri D, Tomitori H, Nishimura K, Kaur N, Phanstiel O 4th, Kitajima M, Takayama H, Okawara T, Williams K, Kashiwagi K, Igarashi K: Comparative studies of anthraquinone- and anthracene-tetraamines as blockers of N-methyl-D-aspartate receptors. J Pharmacol Exp Ther. 2007 Jan;320(1):47-55. Epub 2006 Oct 18.

Anthraquinone spermine [N1-(anthraquinone-2-carbonyl) spermine; AQ343], anthraquinone homospermine [N1-(anthraquinone-2-carbonyl; AQ444], anthracene spermine [N1-(9-anthracenylmethyl) spermine; Ant343], and anthracene homospermine [N1-(9-anthracenylmethyl) homospermine; Ant444] were found to be potent antagonists of recombinant N-methyl-D-aspartate (NMDA) receptors (NRs).
88(1,1,2,3) Details
14764657 Kashiwagi K, Tanaka I, Tamura M, Sugiyama H, Okawara T, Otsuka M, Sabado TN, Williams K, Igarashi K: Anthraquinone polyamines: novel channel blockers to study N-methyl-D-aspartate receptors. J Pharmacol Exp Ther. 2004 Jun;309(3):884-93. Epub 2004 Feb 5.
12(0,0,2,2) Details
17444804 Lin HJ, Lai CC, Lee Chao PD, Fan SS, Tsai Y, Huang SY, Wan L, Tsai FJ: Aloe-emodin metabolites protected N-methyl-d-aspartate-treated retinal ganglion cells by Cu-Zn superoxide dismutase. J Ocul Pharmacol Ther. 2007 Apr;23(2):152-71.


Our previous study had found that aloe-emodin sulfates/glucuronides metabolites, an anthraquinone polyphenol, exerted a neuroprotective activity upon RGCs.
0(0,0,0,0) Details