| Name | luteinizing hormone releasing hormone |
|---|---|
| Synonyms | GNRH; GNRH 1; GNRH1; GRH; GnRH associated peptide I; Gonadoliberin I; Gonadorelin; Gonadotropin releasing hormone 1… |
| Name | anthraquinone |
|---|---|
| CAS | 9,10-anthracenedione |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 1388062 | Szepeshazi K, Schally AV, Juhasz A, Nagy A, Janaky T: Effect of luteinizing hormone-releasing hormone analogs containing cytotoxic radicals on growth of -independent MXT mouse mammary carcinoma in vivo. Anticancer Drugs. 1992 Apr;3(2):109-16. Cytotoxic luteinizing hormone-releasing hormone (LH-RH) analogs, AJ-004 (agonist [D-Lys6] LH-RH linked to methotrexate (MTX)), T-98 ([D-Lys6] LH-RH coupled to glutaryl-2-(hydroxymethyl) anthraquinone) (G-HMAQ) and T-121/B (antagonist containing two residues of G-HMAQ) were tested in female BDF1 mice bearing MXT ((3.2)/Ovex) -independent mammary tumors. |
32(0,1,1,2) | Details |
| 1332035 | Janaky T, Juhasz A, Rekasi Z, Serfozo P, Pinski J, Bokser L, Srkalovic G, Milovanovic S, Redding TW, Halmos G, et al.: Short-chain analogs of luteinizing hormone-releasing hormone containing cytotoxic moieties. Proc Natl Acad Sci U S A. 1992 Nov 1;89(21):10203-7. Alkylating mustards (melphalan, Ac-melphalan), anthraquinone derivatives including anticancer antibiotic doxorubicin, antimetabolite (methotrexate), and cisplatin-like platinum complex were linked to these peptides through their omega-amino group at position 6. |
2(0,0,0,2) | Details |
| 8443402 | Milovanovic SR, Radulovic S, Schally AV: Evaluation of binding of cytotoxic analogs of luteinizing hormone-releasing hormone to human breast cancer and mouse MXT mammary tumor. Breast Cancer Res Treat. 1992;24(2):147-58. Specific binding of [125I] D-Trp6-LH-RH and the cytotoxic LH-RH analog [125I] T-98 ([D-Lys6] LH-RH coupled to glutaryl-2-(hydroxymethyl) anthraquinone) (HMAQG) was demonstrated in membrane preparations from human breast and MXT mammary tumor cells. |
2(0,0,0,2) | Details |
| 8879679 | Szepeshazi K, Schally AV, Halmos G, Szoke B, Groot K, Nagy A: Effect of a cytotoxic analog of LH-RH (T-98) on the growth of -dependent MXT mouse mammary cancers: correlations between growth characteristics and EGF receptor content of tumors. Breast Cancer Res Treat. 1996;40(2):129-39. Female BDF mice bearing -dependent MXT mouse mammary cancers were treated for 4 weeks with a cytotoxic analog of luteinizing hormone-releasing hormone (LH-RH). T-98 (agonist [D-Lys6] LH-RH linked to glutaryl-2 (hydroxymethyl) anthraquinone). |
1(0,0,0,1) | Details |
| 8382705 | Milovanovic SR, Monje E, Szepeshazi K, Radulovic S, Schally A: Effect of treatment with LHRH analogs containing cytotoxic radicals on the binding characteristics of receptors for luteinizing-hormone-releasing hormone in MXT mouse mammary carcinoma. J Cancer Res Clin Oncol. 1993;119(5):273-8. Binding capacities and apparent dissociation constants of receptors for luteinizing-hormone-releasing hormone (LHRH) were investigated in -independent MXT mammary cancers of untreated mice and after in vivo treatment with agonistic or antagonistic analogs of LHRH containing cytotoxic radicals: AJ-04 (agonist [D-Lys6] LHRH linked to methotrexate), T-98-([D-Lys6] LHRH coupled to glutaryl-2-(hydroxmethyl) anthraquinone (G-HMAQ)) and T-121/B (LHRH antagonist T-147 containing two residues of G-HMAQ), which induced tumor growth inhibition. |
88(1,1,1,8) | Details |
| 8477650 | Rekasi Z, Szoke B, Nagy A, Groot K, Rekasi ES, Schally AV: Effect of luteinizing hormone-releasing hormone analogs containing cytotoxic radicals on the function of rat pituitary cells: tests in a long term superfusion system. Endocrinology. 1993 May;132(5):1991-2000. The compounds investigated included two cytotoxic LHRH agonists, T-98 ([D-Lys6] LHRH coupled to glutaryl-2-(hydroxymethyl) anthraquinone (G-HMAQ)) and T-107 ([D-Lys6] LHRH linked to doxorubicin (DOX) through spacer), and two cytotoxic LHRH antagonists T-121 and T-144, both containing two residues of G-HMAQ. |
85(1,1,1,5) | Details |
| 1310542 | Janaky T, Juhasz A, Bajusz S, Csernus V, Srkalovic G, Bokser L, Milovanovic S, Redding TW, Rekasi Z, Nagy A, et al.: Analogues of luteinizing hormone-releasing hormone containing cytotoxic groups. Proc Natl Acad Sci U S A. 1992 Feb 1;89(3):972-6. In an attempt to produce better cytotoxic analogues, chemotherapeutic antineoplastic radicals including an alkylating nitrogen mustard derivative of D- (D-melphalan), reactive cyclopropane, anthraquinone derivatives [2-(hydroxymethyl) anthraquinone and the anticancer antibiotic doxorubicin], and an antimetabolite (methotrexate) were coupled to suitably modified agonists and antagonists of luteinizing hormone-releasing hormone (LH-RH). |
82(1,1,1,2) | Details |
| 8008640 | Szoke B, Horvath J, Halmos G, Rekasi Z, Groot K, Nagy A, Schally AV: LH-RH analogue carrying a cytotoxic radical is internalized by rat pituitary cells in vitro. Peptides. 1994;15(2):359-66. The binding and internalization of a cytotoxic analogue of luteinizing hormone-releasing hormone (LH-RH), T-98 (agonist [D-Lys6] LH-RH linked to glutaryl-2-(hydroxymethyl) anthraquinone), by rat anterior pituitary cells was investigated. |
81(1,1,1,1) | Details |