| Name | glucose 6 phosphate translocase |
|---|---|
| Synonyms | G6PT; G6PT1; G6PT2; G6PT3; GSD1b; GSD1c; GSD1d; Glucose 5 phosphate transporter PRO0685… |
| Name | anthraquinone |
|---|---|
| CAS | 9,10-anthracenedione |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 11426660 | Vertesy L, Kurz M, Paulus EF, Schummer D, Hammann P: The chemical structure of mumbaistatin, a novel glucose-6-phosphate translocase inhibitor produced by Streptomyces sp. J Antibiot. 2001 Apr;54(4):354-63. Mumbaistatin is an anthraquinone derivative, whose open-chain diketo form acts as a specific and powerful inhibitor of glucose-6-phosphate translocase: IC50=5 nM. |
82(1,1,1,2) | Details |
| 17524653 | Lee TS, Das A, Khosla C: Structure-activity relationships of semisynthetic mumbaistatin analogs. Bioorg Med Chem. 2007 Aug 1;15(15):5207-18. Epub 2007 May 23. Mumbaistatin (1), a new anthraquinone natural product, is one of the most potent known inhibitors of hepatic glucose-6-phosphate translocase, an important target for the treatment of type II diabetes. |
81(1,1,1,1) | Details |
| 12492326 | Kaiser F, Schwink L, Velder J, Schmalz HG: Studies toward the total synthesis of mumbaistatin, a highly potent glucose-6-phosphate translocase inhibitor. J Org Chem. 2002 Dec 27;67(26):9248-56. The anthraquinone building block 20 was efficiently prepared via aryne/phthalide annulation. |
2(0,0,0,2) | Details |
| 14966533 | Tang Y, Lee TS, Khosla C: Engineered biosynthesis of regioselectively modified aromatic polyketides using bimodular polyketide synthases. PLoS Biol. 2004 Feb;2(2):E31. Epub 2004 Feb 17. Based upon these findings, hybrid PKSs were engineered to synthesize new anthraquinone antibiotics with predictable functional group modifications. Among the anthracyclines engineered in this study were compounds with (i) more superior activity than R1128 against the breast cancer cell line MCF-7 and (ii) inhibitory activity against glucose-6-phosphate translocase, an attractive target for the treatment of Type II diabetes. |
1(0,0,0,1) | Details |