| Name | interleukin 1 |
|---|---|
| Synonyms | Catabolin; IL 1; IL 1 beta; IL 1B; IL1 beta; IL1B; IL1F2; Interleukin 1… |
| Name | anthraquinone |
|---|---|
| CAS | 9,10-anthracenedione |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17806152 | Savarino L, Fioravanti A, Leo G, Aloisi R, Mian M: Anthraquinone-2,6-disulfonic acid as a disease-modifying osteoarthritis drug: an in vitro and in vivo study. Clin Orthop Relat Res. 2007 Aug;461:231-7. We evaluated the in vitro inhibitory effect of anthraquinone-2,6-disulfonic acid on cathepsin B activity and proteoglycan release from cultured rabbit cartilage challenged with interleukin-1beta in comparison with diacerhein, the prodrug of rhein. |
62(0,2,2,2) | Details |
| 16912431 | de Isla NG, Yang JW, Huselstein C, Muller S, Stoltz JF: IL-1beta synthesis by chondrocyte analyzed by 3D microscopy and flow cytometry: effect of Rhein. Biorheology. 2006;43(3-4):595-601. Diacerein is an anthraquinone molecule that has been shown to reduce the severity of OA, both in man and in animal models. |
7(0,0,0,7) | Details |
| 12193257 | Mendes AF, Caramona MM, de Carvalho AP, Lopes MC: Diacerhein and rhein prevent interleukin-1beta-induced nuclear factor-kappaB activation by inhibiting the degradation of inhibitor kappaB-alpha. Pharmacol Toxicol. 2002 Jul;91(1):22-8. Diacerhein and rhein are anthraquinone compounds that ameliorate the course of osteoarthritis. |
4(0,0,0,4) | Details |
| 2523363 | House RV, Dean JH: Target cell specificity of immunosuppression in murine lymphocytes exposed to 1,4-bis [(2-aminoethyl) amino]-5,8-dihydroxy-9,10-anthracenedione dihydrochloride (AEAD). Int J Immunopharmacol. 1989;11(1):85-93. Exposure of murine lymphocytes to the highly-substituted anthraquinone 1,4-bis [(2-aminoethyl) amino]-5,8-dihydroxy-9,10-anthracenedione dihydrochloride (AEAD) results in a profound suppression of cytotoxic T-lymphocyte function. Production of both IL-1 and IL-2 were normal, and responsiveness to IL-1 was unaltered, although lymphocytes displayed a reduced responsiveness to IL-2. |
1(0,0,0,1) | Details |
| 8118457 | Taccoen A, Berdah L: [Diacetylrhein, a new therapeutic approach of osteoarthritis] . Rev Rhum Ed Fr. 1993 Jul;60(6 Pt 2):83S-86S. Diacerhein is an anthraquinone derivative which is the active ingredient in ART 50. Its unique pharmacological activity involves inhibition of interleukin 1 and cartilage-degrading enzymes. |
1(0,0,0,1) | Details |
| 1535596 | Huang HC, Chang JH, Tung SF, Wu RT, Foegh ML, Chu SH: Immunosuppressive effect of emodin, a free radical generator. Eur J Pharmacol. 1992 Feb 18;211(3):359-64. After 72 h exposure to emodin (10 microM), interleukin-1 (IL-1), interleukin-2 (IL-2) production and IL-2 receptor expression were all reduced. The structure-activity relationship of emodin and 10 other anthraquione derivatives indicates that the free group at the beta-position of the anthraquinone nucleus plays an important role in the immunosuppressive effect. |
1(0,0,0,1) | Details |