Protein Information

Name alkaline phosphatase
Synonyms ALP 1; Alkaline phosphatase; ALPG; ALPPL; ALPPL 2; ALPPL2; GCAP; Germ cell alkaline phosphatase…

Compound Information

Name thiram
CAS

Reference List

PubMed Abstract RScore(About this table)
7897697 Rath NC, Huff WE, Bayyari GR, Balog JM: Effect of thiram on chick chondrocytes in culture. J Toxicol Environ Health. 1995 Mar;44(3):369-76.

Thiram caused a significant reduction in alkaline phosphatase, acid phosphatase, and lactate dehydrogenase (LDH) activities at concentrations of 5 microM and above.
81(1,1,1,1) Details
8226114 Mishra VK, Srivastava MK, Raizada RB: Testicular toxicity of thiram in rat: morphological and biochemical evaluations. Ind Health. 1993;31(2):59-67.

The activity of testicular enzymes such as lactate dehydrogenase (LDH), alkaline phosphatase (ALP), glucose 6-phosphate dehydrogenase (G-6-PDH) were increased significantly in dose dependent manner.
1(0,0,0,1) Details
15899490 Rath NC, Richards MP, Huff WE, Huff GR, Balog JM: Changes in the tibial growth plates of chickens with thiram-induced dyschondroplasia. J Comp Pathol. 2005 Jul;133(1):41-52.

Cell multiplication in the growth plate was determined thereafter with bromodeoxyuridine (BrdU) labelling, and metabolic changes by measuring alkaline phosphatase (ALP), tartrate-resistant acid phosphatase (TRAP), and glutathione (GSH) activities.
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1278353 Zakirov UB, Kadyrov UZ, Volokhvianskii EA: [Effect of different doses of tetramethylthiuram disulfide on the enzyme-forming function of the small intestine]. Farmakol Toksikol. 1976 Mar-Apr;39(2):199-203.


When administered in different doses the compound was found to bring about, in the main, a fall of the monoglyceride-lipase and dipeptidase and a rise of the invertase alkaline-phosphatase and amylolytic activity.
1(0,0,0,1) Details
10375030 Ben-Bassat S, Genina O, Lavelin I, Leach RM, Pines M: Parathyroid receptor gene expression by epiphyseal growth plates in rickets and tibial dyschondroplasia. Mol Cell Endocrinol. 1999 Mar 25;149(1-2):185-95.

PTH/PTHrP receptor gene expression was evaluated in situ in avian epiphyseal growth plates taken from normal, rachitic and tibial dyschondroplasia (TD) afflicted chicks induced by thiram or by genetic selection.
In the normal growth plates, PTH/PTHrP receptor gene expression was localized to the maturation zone as demonstrated by the expression of collagen type II (col II), osteopontin (OPN) genes and alkaline phosphatase activity (AP).
1(0,0,0,1) Details
17307209 Rath NC, Kannan L, Pillai PB, Huff WE, Huff GR, Horst RL, Emmert JL: Evaluation of the efficacy of vitamin D3 or its metabolites on thiram-induced tibial dyschondroplasia in chickens. Res Vet Sci. 2007 Oct;83(2):244-50. Epub 2007 Feb 20.

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