Protein Information

Name glutathione reductase
Synonyms GLUR; GR; GRD 1; GRD1; GRase; GSR; Glutathione reductase; GRases…

Compound Information

Name thiram
CAS

Reference List

PubMed Abstract RScore(About this table)
7649166 Elskens MT, Penninckx MJ: In vitro inactivation of yeast glutathione reductase by tetramethylthiuram disulphide. Eur J Biochem. 1995 Aug 1;231(3):667-72.

The inactivation of glutathione reductase by thiram has now been demonstrated in vitro.
120(1,2,3,5) Details
9212433 Elskens MT, Penninckx MJ: Thiram and dimethyldithiocarbamic acid interconversion in Saccharomyces cerevisiae: a possible metabolic pathway under the control of the glutathione redox cycle. Appl Environ Microbiol. 1997 Jul;63(7):2857-62.

Thiram and dimethyldithiocarbamic acid also inactivate yeast glutathione reductase when the fungicide is present within the cells as the disulfide.
119(1,2,3,4) Details
11516525 Cereser C, Boget S, Parvaz P, Revol A: Thiram-induced cytotoxicity is accompanied by a rapid and drastic oxidation of reduced glutathione with consecutive lipid peroxidation and cell death. Toxicology. 2001 Jun 21;163(2-3):153-62.

Alteration of glutathione levels was accompanied by a dose-dependent decrease in the activity of glutathione reductase (GR), a key enzyme for the regeneration of GSH from GSSG.
1(0,0,0,1) Details
17728093 Grosicka-Maciag E, Kurpios D, Czeczot H, Szumilo M, Skrzycki M, Suchocki P, Rahden-Staron I: Changes in antioxidant defense systems induced by thiram in V79 Chinese hamster fibroblasts. Toxicol In Vitro. 2008 Feb;22(1):28-35. Epub 2007 Jul 26.

We analyzed the catalytic activities of superoxide dismutases (SOD1 and SOD2), Se-dependent and Se-independent glutathione peroxidases (GSH-Px), glutathione reductase (GR), and catalase (CAT), as well as total glutathione/glutathione disulfide ratio (GSH (total)/GSSG).
1(0,0,0,1) Details